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首页> 外文期刊>American Journal of Physiology >A test of biochemical symmorphosis in a heterothermic tissue: bluefin tuna white muscle.
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A test of biochemical symmorphosis in a heterothermic tissue: bluefin tuna white muscle.

机译：异温组织中生化变态的测试：蓝鳍金枪鱼白肌肉。

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摘要

To test predictions of biochemical symmorphosis, we measured the activity of seven consecutive glycolytic enzymes at three positions along the heterothermic white muscle of the bluefin tuna. Biochemical symmorphosis predicts that adjustments in sequential enzyme concentrations along a thermal gradient should occur as a function of the thermal sensitivity of the enzymes to ensure that no one enzyme in the pathway is in excess at any point along the gradient. We found no evidence for adjustments in enzyme quantity or quality along the thermal gradient, as well as no evidence for the prediction that the more temperature-sensitive enzymes would exhibit more dramatic compensation. Conservation of glycolytic flux in the cold exterior and warm interior muscle may be achieved by the near insensitivity of glyceraldehyde-3-phosphate dehydrogenase to temperature in this tissue. This may have the added benefit of moderating flux during seasonal or transient changes in the thermal gradient. According to the strictest application of biochemical symmorphosis, such a mechanism represents adequate, yet suboptimal design.
机译：为了测试生化形态的预测，我们测量了沿蓝鳍金枪鱼异嗜性白肌在三个位置上七个连续糖酵解酶的活性。生化共生学预测，沿着酶梯度的顺序酶浓度的调整应根据酶的热敏感性进行，以确保途径中的任一酶在沿梯度的任何点都不过量。我们没有发现沿热梯度调节酶的数量或质量的证据，也没有预测对温度更敏感的酶会表现出更大补偿的预测的证据。可以通过使3-磷酸甘油醛脱氢酶对组织中的温度不敏感来实现在寒冷的外部和温暖的内部肌肉中糖酵解通量的保存。这可能具有在热梯度的季节性或瞬态变化期间调节通量的额外好处。根据生化共生的最严格的应用，这种机制代表了充分而次优的设计。

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