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首页> 外文期刊>American Journal of Physiology >Strain softening is not present during axial extensions of rat intact right ventricular trabeculae in the presence or absence of 2,3-butanedione monoxime.
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Strain softening is not present during axial extensions of rat intact right ventricular trabeculae in the presence or absence of 2,3-butanedione monoxime.

机译：在存在或不存在2,3-丁二酮一肟的情况下，大鼠完整的右室小梁的轴向延伸过程中不存在应变软化。

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摘要

Recent studies of passive myocardial mechanics have shown that strain softening behavior is present during both inflation of isolated whole rat hearts and shearing of tissue blocks taken from the left ventricular free wall in pigs. Strain softening is typically manifested by a stiffer force-extension relation in the first deformation cycle relative to subsequent cycles and is distinguished from viscoelasticity by a lack of recovery of stiffness, even after several hours of rest. The causes of this behaviour are unknown. We investigated whether strain softening is observed in uniaxial extensions of intact, viable, rat right ventricular (RV) cardiac trabeculae. Stretch and release cycles of 5%, 10%, and 15% muscle length were applied at a constant velocity at 26 degrees C. Muscles were tested in random order in the presence and absence of 50 mM 2,3-butanedione monoxime (BDM). Whereas strain softening was displayed by nonviable trabeculae, it was not observed in viable preparations undergoing physiologically relevant extensions whether in the presence or absence of BDM. BDM also had no effect on passive compliance. There was a reversible increase of muscle compliance between the first and subsequent cycles, with recovery after 30 s of rest, independent of the presence of BDM. We conclude that strain softening is neither intrinsic to viable rat RV trabeculae nor influenced by BDM and that passive trabeculae compliance is not altered by the addition of BDM.
机译：被动心肌力学的最新研究表明，在孤立的整个大鼠心脏膨胀和从猪左心室游离壁获取的组织块剪切期间，都存在应变软化行为。应变软化通常表现为在第一个变形循环中相对于随后的循环而言，刚度与刚度的关系更强，并且即使在静止数小时后也无法恢复刚度，从而与粘弹性区分开来。此行为的原因未知。我们调查了是否在完整，可行的大鼠右心室（RV）心脏小梁的单轴延伸中观察到应变软化。在26°C下以恒定速度施加5％，10％和15％肌肉长度的拉伸和释放循环。在存在和不存在50 mM 2,3-丁二酮单肟（BDM）的情况下，以随机顺序测试肌肉。尽管无活力的小梁显示出了应变软化，但无论是否存在BDM，在进行生理相关延伸的可行制剂中均未观察到应变软化。 BDM对被动遵从也没有影响。在第一个和随后的周期之间，肌肉顺应性可逆地增加，休息30 s后恢复，与BDM的存在无关。我们得出的结论是，应变软化既不是可行的大鼠RV小梁固有的，也不是受BDM的影响，并且添加BDM不会改变被动小梁的顺应性。

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