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首页> 外文期刊>American Journal of Physiology >A role for NPY overexpression in the dorsomedial hypothalamus in hyperphagia and obesity of OLETF rats.
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A role for NPY overexpression in the dorsomedial hypothalamus in hyperphagia and obesity of OLETF rats.

机译：NPY过表达在OLETF大鼠食欲亢进和肥胖的背侧下丘脑中的作用。

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摘要

Otsuka Long-Evans Tokushima Fatty (OLETF) rats lacking CCK-A receptors are hyperphagic, obese, and diabetic. We have previously demonstrated that these rats have a peripheral satiety deficit resulting in increased meal size. To examine the potential role of hypothalamic pathways in the hyperphagia and obesity of OLETF rats, we compared patterns of hypothalamic neuropeptide Y (NPY), proopiomelanocortin (POMC), and leptin receptor mRNA expression in ad libitum-fed Long-Evans Tokushima (LETO) and OLETF rats and food-restricted OLETF rats that were pair-fed to the intake of LETO controls. Pair feeding OLETF rats prevented their increased body weight and elevated levels of plasma insulin and leptin and normalized their elevated POMC and decreased NPY mRNA expression in the arcuate nucleus. In contrast, NPY expression was upregulated in the dorsomedial hypothalamus (DMH) in pair-fed OLETF rats. A similar DMH NPY overexpression was evident in 5-wk-old preobese OLETF rats. These findings suggest a role for DMHNPY upregulation in the etiology of OLETF hyperphagia and obesity.
机译：缺乏CCK-A受体的Otsuka Long-Evans Tokushima Fatty（OLETF）大鼠是食欲亢进，肥胖和糖尿病。先前我们已经证明这些大鼠具有周围饱腹感不足，导致进餐量增加。为了检查下丘脑途径在OLETF大鼠食欲亢进和肥胖中的潜在作用，我们比较了随意喂养的长伊文思德岛（LETO）下丘脑神经肽Y（NPY），促黑素皮质激素（POMC）和瘦素受体mRNA表达的模式。配对喂食LETO对照的OLETF大鼠和食物受限的OLETF大鼠。配对喂养的OLETF大鼠可以防止其体重增加，血浆胰岛素和瘦素水平升高，并使弓形核中POMC升高和NPY mRNA表达降低。相反，成对喂养的OLETF大鼠的背部丘脑下丘脑（DMH）中的NPY表达上调。在5周龄的肥胖肥胖ETF大鼠中也出现了类似的DMH NPY过表达。这些发现表明DMHNPY上调在OLETF食欲亢进和肥胖的病因中起作用。

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