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首页> 外文期刊>American Journal of Physiology >Vagal cardiac function and arterial blood pressure stability.
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Vagal cardiac function and arterial blood pressure stability.

机译：迷走神经心脏功能和动脉血压稳定。

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This study was designed to investigate the importance of vagal cardiac modulation in arterial blood pressure (ABP) stability before and after glycopyrrolate or atropine treatment. Changes in R-R interval (RRI) and ABP were assessed in 10 healthy young (age, 22 +/- 1.8 yr) volunteers during graded lower body negative pressure (LBNP) before and after muscarinic cholinergic (MC) blockade. Transient hypertension was induced by phenylephrine (1 microg/kg body wt), whereas systemic hypotension was induced by bilateral thigh cuff deflation after a 3-min suprasystolic occlusion. Power spectral densities of systolic [systolic blood pressure (SBP)] and diastolic ABP variability were examined. Both antimuscarinic agents elicited tachycardia similarly without significantly affecting baseline ABP. The increase in SBP after phenylephrine injection (+14 +/- 2 mmHg) was significantly augmented with atropine (+26 +/- 2 mmHg) or glycopyrrolate (+27 +/- 3 mmHg) and associated with a diminished reflex bradycardia. The decrease in SBP after cuff deflation (-9.2 +/- 1.2 mmHg) was significantly greater after atropine (-15 +/- 1 mmHg) or glycopyrrolate (-14 +/- 1 mmHg), with abolished reflex tachycardia. LBNP significantly decreased both SBP and RRI. However, after antimuscarinic agents, the reduction in SBP was greater (P < 0.05) and was associated with less tachycardia. Antimuscarinic agents reduced (P < 0.05) the low-frequency (LF; 0.04-0.12 Hz) power of ABP variability at rest. The LF SBP oscillation was significantly augmented during LBNP, which was accentuated (P < 0.05) after antimuscarinic agents and was correlated (r = -0.79) with the decrease in SBP. We conclude that antimuscarinic agents compromised ABP stability by diminishing baroreflex sensitivity, reflecting the importance of vagal cardiac function in hemodynamic homeostasis. The difference between atropine and glycopyrrolate was not significant.
机译：这项研究旨在调查迷迭香心脏调节剂在格隆溴铵或阿托品治疗前后对动脉血压（ABP）稳定性的重要性。在毒蕈碱胆碱能（MC）阻断前后，对10位健康的年轻人（22岁+/- 1.8岁）志愿者进行了分级下体负压（LBNP）期间，评估了R-R间隔（RRI）和ABP的变化。短暂性高血压是由去氧肾上腺素（1 microg / kg体重）引起的，而全身性低血压是由收缩期3分钟闭塞后双侧大腿袖带放气引起的。检查收缩压[收缩压（SBP）]的功率谱密度和舒张压ABP的变异性。两种抗毒蕈碱剂均引起心动过速，而不会显着影响基线ABP。注射去氧肾上腺素（+14 +/- 2 mmHg）后的SBP升高与阿托品（+26 +/- 2 mmHg）或格隆溴铵（+27 +/- 3 mmHg）显着增强，并伴有反射性心动过缓减弱。阿托品（-15 +/- 1 mmHg）或格隆溴铵（-14 +/- 1 mmHg）消失后，袖带放气后SBP的降低（-9.2 +/- 1.2 mmHg）明显更大，而反射性心动过速消失。 LBNP显着降低SBP和RRI。然而，使用抗毒蕈碱药物后，SBP的降低更大（P <0.05），并伴有较少的心动过速。抗毒蕈碱药降低（P <0.05）静止时ABP变异性的低频（LF; 0.04-0.12 Hz）功效。 LBNP期间LF SBP振荡显着增强，在抗毒蕈碱药物后LF SBP振荡加剧（P <0.05），并且与SBP降低相关（r = -0.79）。我们得出的结论是，抗毒蕈碱药物通过降低压力反射敏感性而损害了ABP的稳定性，反映了迷走性心脏功能在血流动力学稳态中的重要性。阿托品和格隆溴铵之间的差异不显着。

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