Sensory Mechanism of Oxygen Sensor FixL

Hideyuki MIYATAKE; Yoshitsugu SHIRO

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Sensory Mechanism of Oxygen Sensor FixL

机译：氧传感器固定装置的感觉机制

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FixL is a sensor histidine kinase of the two component system, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to the O_2 levels. The crystal structure of the sensor domain of FixL, which contains a heme as a sensing site, was determined at 1.4 A resolution. Based on the structure, we propose the O_2 sensing mechanism: conformational changes in the distal side of the heme, which are induced by steric repulsion between the bent-bound O_2 and the Ile209 side chain, would be transmitted to the histidine kinase domain. Our mechanism permits FixL to serve a real oxygen sensor, which can distinguish bent-bound O_2 to other liner-hound ligands.

机译：FixL是两个组分系统的传感器组氨酸激酶，其调节与O_2水平的根结节中的氮固定相关的基因的表达。在1.4分辨率下测定含有血红素的夹具的传感器结构域的晶体结构。基于该结构，我们提出了O_2传感机制：通过在弯曲的O_2和ILE209侧链之间通过空间排斥诱导的血红素的远端侧的构象变化将被传递到组氨酸激酶结构域。我们的机制允许FixL用于真正的氧传感器，可以将弯曲的O_2区分离给其他衬里 - 捕猎配体。

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《日本结晶学会志》 |2001年第2期|共6页
作者
Hideyuki MIYATAKE; Yoshitsugu SHIRO;
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1. Sensory Mechanism of Oxygen Sensor FixL [J] . Hideyuki MIYATAKE, Yoshitsugu SHIRO 日本结晶学会志 . 2001,第2期

机译：氧气传感器FixL的感觉机制
2. Sensory mechanism of oxygen sensor FixL from Rhizobium meliloti: crystallographic, mutagenesis and resonance Raman spectroscopic studies. [J] . Miyatake H, Mukai M, Park SY, Journal of Molecular Biology . 2000,第2期

机译：苜蓿根瘤菌氧传感器FixL的感官机制：晶体学，诱变和共振拉曼光谱研究。
3. Mechanisms of autoxidation of the oxygen sensor FixL and Aplysia myoglobin: Implications for oxygen-binding heme proteins [J] . Gonzalez G., Rybak-Akimova EV., Buchalova M., Biochemistry . 1998,第28期

机译：氧传感器FixL和Aplysia肌红蛋白的自氧化机制：对氧结合血红素蛋白的影响
4. Proton NMR Characterization of Recombinant Ferric Heme Domains of the Oxygen Sensors FixL and Dos: Evidence for Protein Heterogeneity [C] . James D. Satterlee, Christine M. Suquet, Marina I. Savenkova, American Chemical Society national meeting . 2003

机译：氧传感器滤光器和DOS的重组亚血管结构域的质子NMR表征：蛋白质异质性的证据
5. Spectroscopic and kinetic studies of FixL, the heme-based oxygen-sensing protein from Sinorhizobium meliloti: Implications for the mechanism of signal transduction. [D] . Tang, Lei. 2004

机译：FixL（一种来自血缘中华根瘤菌的基于血红素的氧敏感蛋白）的光谱和动力学研究：对信号转导机制的影响。
6. Ultrafast ligand rebinding in the heme domain of the oxygen sensors FixL and Dos: General regulatory implications for heme-based sensors [O] . Ursula Liebl, Latifa Bouzhir-Sima, Michel Négrerie, 2002

机译：氧传感器FixL和Dos血红素域中的超快配体重结合：基于血红素的传感器的一般法规含义
7. Subpicosecond Oxygen Trapping in the Heme Pocket of the Oxygen Sensor FixL Observed by Time-Resolved Resonance Raman Spectroscopy [O] . Kruglik, Sergei,, Jasaitis, Audrius, Hola, Klara, 2007

机译：时间分辨共振拉曼光谱法观察氧传感器FixL血红素口袋中的亚皮秒氧捕集

Sensory Mechanism of Oxygen Sensor FixL

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