Structural Biological Study of Biliverdin Reductase

Akihiro KIKUCHI

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Structural Biological Study of Biliverdin Reductase

机译：Biliverdin还原酶的结构生物学研究

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In mammals, heme is degraded to biliverdin by heme oxygenase (HO) and subsequently, the biliverdin is reduced to bilirubin by biliverdin reductase (BVR). The metabolic waste product, bilirubin is now becoming recognized as having functional importance. It appears to play a key role in oxidative stress defense in vivo. Thus, heme degradation pathway has seen renewed interest in its biosynthesis. Recently, the X-ray crystal structures of HO and BVR were determined. Based on the structures, new insights into the mechanism of the heme degradation and bilirubin synthesis are discussed.

机译：在哺乳动物中，血红素通过血红素氧酶（HO）降解到Biliverdin，随后，通过Biliverdin还原酶（BVR）将Biliverdin降至胆红素。代谢废物产品，胆红素现在被认为具有功能性重要性。它似乎在体内氧化压力防御中发挥着关键作用。因此，血红液降解途径已在其生物合成中兴趣再次感兴趣。最近，确定了HO和BVR的X射线晶体结构。基于结构，讨论了新的洞察血红液降解和胆红素合成的机理。

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《日本结晶学会志》 |2001年第5期|共6页
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Akihiro KIKUCHI;
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中图分类晶体学;
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1. Structural Biological Study of Biliverdin Reductase [J] . Akihiro KIKUCHI 日本结晶学会志 . 2001,第5期

机译：Biliverdin还原酶的结构生物学研究
2. In silico and crystallographic studies identify key structural features of biliverdin IXβ reductase inhibitors having nanomolar potency [J] . Natasha Nesbitt, Xiliang Zheng, Zongdong Li, The Journal of biological chemistry . 2018,第15期

机译：在计算机和晶体学研究中确定了具有纳摩尔浓度的biliverdinIXβ还原酶抑制剂的关键结构特征
3. In silico and crystallographic studies identify key structural features of biliverdin IXβ reductase inhibitors having nanomolar potency [J] . Natasha Nesbitt, Xiliang Zheng, Zongdong Li, The Journal of biological chemistry . 2018,第15期

机译：在计算机和晶体学研究中确定了具有纳摩尔浓度的biliverdinIXβ还原酶抑制剂的关键结构特征
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机译：新型醛基酮还原酶（AKRS）从3-羟基丁二醛向1,3-丁二酚的生物催化转化的结构和生物化学研究
5. Studies on 4-vinyl protochlorophyllide reductase and the biological significance of the divinyl and monovinyl monocarboxylic chlorophyll a biosynthetic routes [D] . Fasoula, Dionysia Apostolos 1994

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6. In silico and crystallographic studies identify key structural features of biliverdin IXβ reductase inhibitors having nanomolar potency [O] . Natasha M. Nesbitt, Xiliang Zheng, Zongdong Li, 2018

机译：在计算机和晶体学研究中确定了具有纳摩尔浓度的biliverdinIXβ还原酶抑制剂的关键结构特征
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机译：分枝杆菌结核杆菌 - ACP（COA）还原酶酶硅鉴定抑制剂的功能，热力学，结构和生物学研究

Structural Biological Study of Biliverdin Reductase

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