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首页> 外文期刊>American Journal of Physiology >Mechanism of increased vessel wall nitric oxide concentrations during intestinal absorption.
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Mechanism of increased vessel wall nitric oxide concentrations during intestinal absorption.

机译：肠道吸收过程中血管壁一氧化氮浓度增加的机理。

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摘要

Vasoactive compounds, including nitric oxide (NO) and hypertonic sodium, may diffuse from venous endothelial cells and blood to the arterial wall during intestinal absorption. This hypothesis was tested by measuring the perivascular NO concentration ([NO]) for paired small arteries and veins with NO-sensitive microelectrodes. Resting arterial and venous wall concentrations for nine vessel pairs (5 rats) were 353 +/- 28 and 401 +/- 48 (SE) nM. During mucosal absorption of 100 and 300 mg/dl glucose, the artery dilated 12 +/- 1.5 and 17 +/- 2%, [NO] increased to 540 +/- 68 and 550 +/- 49 nM, and venous wall [NO] increased to 557 +/- 60 and 633 +/- 70 nM. During venous occlusion to block diffusion of materials from venous blood to the artery wall, the arterial and venous [NO] decreased by 70-80%, and one-half of the arterial dilation subsided. Superfusion with 320 and 360 mosmol/l hypertonic sodium medium to simulate the sodium hyperosmolarity during mucosal absorption of glucose increased the arterial [NO] by 20-30 and 40-50%; 360 mosmol/l saline made hypertonic with mannitol did not significantly increase the [NO]. Although venous to arterial diffusion of NO occurred, the increased arterial [NO] during mucosal glucose absorption was primarily generated by the arterial wall in response to materials that diffused from venous blood, such as hypertonic sodium.
机译：在肠道吸收过程中，包括一氧化氮（NO）和高渗钠在内的血管活性化合物可能会从静脉内皮细胞和血液扩散到动脉壁。通过用NO敏感的微电极测量成对的小动脉和静脉的血管周围NO浓度（[NO]），检验了该假设。 9对血管（5只大鼠）的静息动脉和静脉壁浓度为353 +/- 28和401 +/- 48（SE）nM。在100和300 mg / dl葡萄糖的粘膜吸收过程中，动脉扩张12 +/- 1.5和17 +/- 2％，[NO]增至540 +/- 68和550 +/- 49 nM，静脉壁[ NO]增加到557 +/- 60和633 +/- 70 nM。在静脉阻塞以阻止物质从静脉血扩散到动脉壁的过程中，动脉和静脉[NO]降低了70-80％，一半的动脉扩张消退了。用320和360 mosmol / l高渗钠介质进行的超级灌注可模拟葡萄糖在粘膜吸收过程中的钠渗透压升高，使动脉[NO]升高20-30和40-50％。用甘露醇高渗的360 mosmol / l盐水并未显着增加[NO]。尽管发生了从静脉到动脉的NO扩散，但粘膜葡萄糖吸收过程中动脉[NO]的增加主要是由动脉壁响应于从静脉血液扩散的物质（如高渗钠）而产生的。

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