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首页> 外文期刊>American Journal of Physiology >Selective effect of tempol on renal medullary hemodynamics in spontaneously hypertensive rats.
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Selective effect of tempol on renal medullary hemodynamics in spontaneously hypertensive rats.

机译：tempol对自发性高血压大鼠肾髓质血流动力学的选择性作用。

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摘要

The present study assessed the short- and long-term effect of tempol, a membrane-permeable mimetic of superoxide dismutase, on renal medullary hemodynamics in spontaneously hypertensive rats (SHR). Tempol was given in the drinking water (1 mM) for 4 days or 7 wk (4-11 wk of age), and medullary blood flow (MBF) was measured over a wide range of renal arterial pressure by means of laser-Doppler flowmetry in anesthetized rats. In addition, the response of the medullary circulation to angiotensin II (5-50 ng x kg(-1) x min(-1) iv) was determined in SHR treated for 4 days with tempol. Compared with control SHR, short- and long-term treatment with tempol decreased arterial pressure by approximately 20 mmHg and increased MBF by 35-50% without altering total renal blood flow (RBF) or autoregulation of RBF. Angiotensin II decreased RBF and MBF dose dependently (approximately 30% at the highest dose) in control SHR. In SHR treated with tempol, angiotensin II decreased RBF (approximately 30% at the highest dose) but did not alter MBF significantly. These data indicate that the antihypertensive effect of short- and long-term administration of tempol in SHR is associated with a selective increase in MBF. Tempol also reduced the sensitivity of MBF to angiotensin II. Taken together, these data support the idea that tempol enhances vasodilator mechanisms of the medullary circulation, possibly by interacting with the nitric oxide system. Increased MBF and reduced sensitivity of MBF to angiotensin II may contribute to the antihypertensive action of tempol in SHR.
机译：本研究评估了自发性高血压大鼠（SHR）的膜透性超氧化物歧化酶tempol对肾髓质血流动力学的短期和长期影响。在饮用水（1 mM）中给予Tempol 4天或7 wk（年龄4-11 wk），并通过激光多普勒血流仪在广泛的肾动脉压范围内测量髓样血流（MBF）在麻醉的大鼠中。此外，在用tempol处理4天的SHR中确定了髓样循环对血管紧张素II的反应（5-50 ng x kg（-1）x min（-1）iv）。与对照SHR相比，用tempol进行的短期和长期治疗可使动脉压降低约20 mmHg，MBF升高35-50％，而不会改变总肾血流量（RBF）或RBF的自动调节。在对照SHR中，血管紧张素II降低了RBF和MBF剂量（在最高剂量下约为30％）。在用tempol治疗的SHR中，血管紧张素II降低了RBF（最高剂量时约为30％），但并未显着改变MBF。这些数据表明，在SHR中短期和长期服用tempol的抗高血压作用与MBF的选择性升高有关。 Tempol还降低了MBF对血管紧张素II的敏感性。综上所述，这些数据支持了tempol可能通过与一氧化氮系统相互作用来增强髓样循环的血管扩张机制的观点。 MBF的增加和MBF对血管紧张素II的敏感性降低可能有助于tempol在SHR中的降压作用。

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