• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Physiology >Microbes and microbial toxins: paradigms for microbial-mucosal interactions II. The integrated response of the intestine to Clostridium difficile toxins.
【24h】

Microbes and microbial toxins: paradigms for microbial-mucosal interactions II. The integrated response of the intestine to Clostridium difficile toxins.

机译：微生物和微生物毒素：微生物-粘膜相互作用的范例II。肠道对艰难梭菌毒素的综合反应。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Clostridium difficile, the major etiologic factor of antibiotic-associated diarrhea and colitis, mediates its effects by releasing two large protein exotoxins, toxins A and B. A major toxin effect is related to the disassembly of actin microfilaments, leading to impairment of tight junctions in human colonocytes. The mechanism of actin disaggregation involves monoglucosylation of the signaling proteins Rho A, Rac, and Cdc 42, which control stress fiber formation directly by toxins A and B. An important aspect of C. difficile infection is the acute necroinflammatory changes seen in patients with pseudomembranous colitis. The early mechanism of toxin-mediated inflammation involves toxin effects on cellular mitochondria, release of reactive oxygen species, and activation of mitogen-activated protein kinases and the transcription factor nuclear factor-kappaB. Injection of toxin A into animal intestine triggers secretion of fluid and intestinal inflammation characterized by epithelial cell destruction and neutrophil activation. A critical feature of C. difficile enterotoxicity is communication between enterocytes and lamina propria nerves, macrophages, and mast cells mediated via release of neuropeptides and proinflammatory cytokines.
机译：艰难梭菌是抗生素相关性腹泻和结肠炎的主要病因，它通过释放两种大的蛋白质外毒素毒素A和B来介导其作用。主要毒素作用与肌动蛋白微丝的分解有关，从而导致肌动蛋白微丝紧密连接的破坏。人结肠细胞。肌动蛋白分解的机制涉及信号蛋白Rho A，Rac和Cdc 42的单糖基化，它们直接控制毒素A和B形成应激纤维的形成。艰难梭菌感染的一个重要方面是假膜性患者的急性坏死性炎症改变。结肠炎。毒素介导的炎症的早期机制涉及毒素对细胞线粒体的影响，活性氧的释放以及丝裂原激活的蛋白激酶和转录因子核因子-κB的活化。将毒素A注射到动物肠道中会触发以上皮细胞破坏和嗜中性粒细胞活化为特征的体液和肠道炎症的分泌。艰难梭菌肠毒性的一个关键特征是通过释放神经肽和促炎细胞因子介导的肠上皮细胞与固有层神经，巨噬细胞和肥大细胞之间的通讯。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号