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首页> 外文期刊>American Journal of Physiology >Hypoxic vasoconstriction of cyclostome systemic vessels: the antecedent of hypoxic pulmonary vasoconstriction?
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Hypoxic vasoconstriction of cyclostome systemic vessels: the antecedent of hypoxic pulmonary vasoconstriction?

机译：环吻系统性血管的低氧血管收缩：低氧性肺血管收缩的先决条件？

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摘要

Hypoxic vasoconstriction (HV) is an intrinsic response of mammalian pulmonary vascular smooth muscle (VSM). In the present study, HV was examined by myography of vessel rings from three primitive vertebrates: New Zealand hagfish (NZH), Pacific hagfish (PH), and sea lamprey (SL). Hypoxia dilated pre-gill arteries (ventral aorta, afferent branchial) from all species, whereas it contracted systemic arteries [dorsal aorta (DA), efferent branchial, celiacomesenteric]. DA HV was reproducible over several days, and it could be sustained in NZH for 8 h without adverse effects. Tension was proportional to PO(2), and half-maximal HV was obtained at PO(2) (mmHg) of 4.7 +/- 0. 2 (NZH), 0.8 +/- 0.1 (PH), and 10.7 +/- 1.9 (SL). HV did not require preconditioning (preexisting contractile stimulus) and was unaffected by elevated extracellular potassium (200 mM NZH; 80 mM SL); removal of the endothelium (NZH); or inhibitors of cyclooxygenase, lipoxygenase, cytochrome P-450 or antagonists of alpha-adrenergic, muscarinic, nicotinic, purinergic, or serotoninergic receptors. These results show that HV is an intrinsic feature of systemic VSM in cyclostomes and suggest that HV has been in the repertoire of VSM responses, since the origin of vertebrates. The exceptionally hardy HV in cyclostome DA may provide a useful model with which to examine both the phylogeny and mechanisms of this response.
机译：缺氧性血管收缩（HV）是哺乳动物肺血管平滑肌（VSM）的内在反应。在本研究中，通过对来自三个原始脊椎动物的血管环的肌电图检查来检查HV：新西兰New鱼（NZH），太平洋ha鱼（PH）和海七lamp鱼（SL）。缺氧使所有物种的pre前动脉（腹主动脉，传入分支）扩张，而它收缩全身动脉[背主动脉（DA），传出分支，celiacomesenteric]。 DA HV可在几天内重现，并且可以在NZH中维持8小时而无不良影响。张力与PO（2）成正比，并且在PO（2）（mmHg）为4.7 +/- 0.2（NZH），0.8 +/- 0.1（PH）和10.7 +/-时获得最大HV 1.9（SL）。 HV不需要预处理（已有收缩刺激），并且不受细胞外钾离子升高（200 mM NZH; 80 mM SL）的影响;去除内皮（NZH）;或环加氧酶，脂氧合酶，细胞色素P-450的抑制剂或α-肾上腺素，毒蕈碱，烟碱，嘌呤能或5-羟色胺能受体的拮抗剂。这些结果表明，HV是环行气孔系统性VSM的固有特征，并表明自脊椎动物起源以来，HV一直存在于VSM反应库中。环吻DA中异常强壮的HV可能会提供一个有用的模型，用以检查这种反应的系统发育和机制。

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