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首页> 外文期刊>American Journal of Physiology >Hemodynamics of anesthetized ventilated mouse models: aspects of anesthetics, fluid support, and strain.
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Hemodynamics of anesthetized ventilated mouse models: aspects of anesthetics, fluid support, and strain.

机译：麻醉通风的小鼠模型的血流动力学：麻醉剂，液体支持和应变方面。

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This study evaluates the effects of anesthesia and fluid support on hemodynamic parameters of the mechanically ventilated mouse of four different strains. All experiments were performed at a similar surgical level of anesthesia, as indicated by the probing of the pedal withdrawal reflex. Three anesthetic regimens [fentanyl-fluanisone-midazolam (FFM), ketamine-medetomidine-atropine (KMA), and isoflurane (ISO)], four commonly used mouse strains (Swiss, CD-1, BalbC, and C57Bl6), and three different fluid support strategies (no fluid, 0.2 ml x h(-1) x 10 g(-1) of 6% polystarch solution, and 0.5 ml x h(-1) x 10 g(-1) saline) were studied. Mean arterial pressure (MAP) or heart rate (HR) was similar among the four strains of mice except a trend toward lower HR for the BalbC mice. In terms of MAP, KMA is the preferred anesthetic for the Swiss and CD-1 mice, whereas KMA or ISO are recommended for BalbC or C57Bl6 mice. In terms of HR, ISO is the preferred anesthetic for the Swiss, CD-1, and C57Bl6 strains. No differences in HR for the three anesthetics were observed for the BalbC strain. Compared with administration of no fluid, both saline and polystarch administration similarly increased MAP by 7 +/- 2, 10 +/- 2, and 11 +/- 2 mmHg at t = 1, 2, and 3 h, respectively, whereas fluid administration was without effect on HR. Saline supplementation resulted in an increased dry-to-wet ratio of the heart and both fluid regimens decreased total hemoglobin in the blood from 12.6 +/- 0.5 to 10.4 +/- 0.5 g/100 ml. Saline administration was associated with blood acidosis (pH 7.20 +/- 0.03) compared with the Haes (pH 7.29 +/- 0.02) or no-fluid group (pH 7.34 +/- 0.03), whereas PCO(2) was approximately 30 mmHg for all groups. We conclude that at similar surgical levels of anesthesia, the preferable type of anesthesia (ISO or KMA, but never FFM) depends on the strain used and whether MAP or HR is the focus of study. Additional fluid support is beneficial in terms of raising arterial blood pressure, although this is at the cost of changes in organ water content and increased anemia.
机译：这项研究评估了麻醉和液体支持对四种不同品系的机械通气小鼠血液动力学参数的影响。所有实验均在相似的手术麻醉水平下进行，如脚踏板缩回反射的探测所示。三种麻醉方案[芬太尼-氟胺酮-咪达唑仑（FFM），氯胺酮-美托咪定-阿托品（KMA）和异氟烷（ISO）]，四种常用小鼠品系（瑞士，CD-1，BalbC和C57Bl6）流体支持策略（无流体，0.2 ml xh（-1）x 10 g（-1）的6％聚淀粉溶液和0.5 ml xh（-1）x 10 g（-1）盐水）进行了研究。除BalbC小鼠的HR降低趋势外，四种小鼠的平均动脉压（MAP）或心率（HR）相似。就MAP而言，KMA是Swiss和CD-1小鼠的首选麻醉剂，而BalaC或C57B16小鼠则建议使用KMA或ISO。就HR而言，ISO是Swiss，CD-1和C57B16菌株的首选麻醉剂。对于BalbC菌株，未观察到三种麻醉药的HR差异。与不加液相比，在t = 1、2和3 h时，盐水和多淀粉给药分别使MAP分别升高了7 +/- 2、10 +/- 2和11 +/- 2 mmHg，而液体给药对HR没有影响。补充盐水会增加心脏的干湿比，并且两种液体疗法都会使血液中的总血红蛋白从12.6 +/- 0.5降低到10.4 +/- 0.5 g / 100 ml。与Haes（pH 7.29 +/- 0.02）或无液组（pH 7.34 +/- 0.03）相比，盐水给药与血液酸中毒（pH 7.20 +/- 0.03）相关，而PCO（2）约为30 mmHg对于所有群体。我们得出的结论是，在相似的手术麻醉水平下，优选的麻醉类型（ISO或KMA，但绝不使用FFM）取决于所用的应变以及MAP或HR是研究重点。尽管以增加器官水分含量和增加贫血为代价，但是额外的液体支持在提高动脉血压方面是有益的。

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