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首页> 外文期刊>American Journal of Physiology >Local, exendin-(9-39)-insensitive, site of action of GLP-1 in canine ileum.
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Local, exendin-(9-39)-insensitive, site of action of GLP-1 in canine ileum.

机译：犬回肠中GLP-1的局部，对exendin-（9-39）不敏感的作用位点。

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摘要

Glucagon-like peptide-1 (GLP-1) modulates glucose levels following a meal, including by inhibition of gastric emptying and intestinal transport. Intra-arterial injection of GLP-1 into the gastric corpus, antrum, or pylorus of anesthetized dogs had no effect on the contractile activity of the resting or neurally activated stomach. GLP-1 injected intra-arterially inhibited intestinal segments when activated by enteric nerve stimulation but not by acetylcholine. Isolated ileum segments were perfused intra-arterially, instrumented with strain gauges to record circular muscle activity and with subserosal electrodes to stimulate enteric nerves. GLP-1 caused concentration-dependent inhibition of nerve-stimulated phasic but not tonic activity. This was absent during TTX-induced activity and partly prevented by N(G)-nitro-L-arginine. Exendin-(9-39), the GLP-1 antagonist, had no intrinsic activity and did not affect the actions of GLP-1. Capsaicin mimicked the effects of GLP-1 and may have reduced the effect of subsequent GLP-1. GLP-1 may mediate paracrine action on afferent nerves in the canine ileal mucosa using an unusual receptor.
机译：餐后胰高血糖素样肽1（GLP-1）可以调节血糖水平，包括抑制胃排空和肠道运输。向麻醉犬的胃体，胃窦或幽门动脉内注射GLP-1对静息或神经激活的胃的收缩活动没有影响。当通过肠神经刺激而不是通过乙酰胆碱激活时，动脉内注射的GLP-1可抑制肠段。分离的回肠段在动脉内灌注，用应变仪测量以记录环形肌肉活动，并用浆膜下电极刺激肠神经。 GLP-1引起神经刺激的阶段性的浓度依赖性抑制，但不引起补品活性。这在TTX诱导的活性中不存在，部分被N（G）-硝基-L-精氨酸所阻止。 Exendin-（9-39），GLP-1拮抗剂，没有内在活性，也不影响GLP-1的作用。辣椒素模拟了GLP-1的作用，并可能降低了后续GLP-1的作用。 GLP-1可能会使用异常受体介导旁肠对犬回肠粘膜传入神经的旁分泌作用。

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