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首页> 外文期刊>American Journal of Physiology >T cell receptor delta repertoire in inflamed and noninflamed colon of patients with IBD analyzed by CDR3 spectratyping.
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T cell receptor delta repertoire in inflamed and noninflamed colon of patients with IBD analyzed by CDR3 spectratyping.

机译：通过CDR3光谱分析分析了IBD患者发炎和未发炎结肠中的T细胞受体δ组成。

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摘要

Gamma/delta T cells might play an important role in autoimmune conditions like inflammatory bowel disease (IBD). In the present study, we characterized the T cell receptor (TCR)-delta repertoire by complementarity determining region 3 (CDR3) spectratyping in the inflamed and noninflamed mucosa and in the peripheral blood of subjects with Crohn's disease and ulcerative colitis. In contrast to previously published data about alpha/beta T cells, we rarely found oligoclonal expansions of gamma/delta T cells specific only for the inflamed mucosa. The same dominant gamma/delta T cell expansions were also present in the noninflamed colon. Furthermore, the peripheral gamma/delta TCR repertoire was oligoclonal but clearly distinct from that in the inflamed intestine. Thus our results do not support a role for antigen-specific gamma/delta T cells in IBD, and dominant gamma/delta T cells of the peripheral blood are not likely to be derived from the inflamed gut. However, in several patients, the TCR-delta-repertoire was highly diversified, whereas in others we observed a loss of dominant gamma/delta T cell clones when inflamed and noninflamed mucosa were compared. In conclusion, those changes indicate that gamma/delta T cells might play an important role in a subset of patients with IBD.
机译：γ/δT细胞可能在自身免疫性疾病如炎症性肠病（IBD）中起重要作用。在本研究中，我们通过在克罗恩病和溃疡性结肠炎患者的发炎和未发炎的粘膜和外周血中的互补决定区3（CDR3）谱型表征了T细胞受体（TCR）-δ谱系。与先前发布的有关α/βT细胞的数据相反，我们很少发现仅对发炎的粘膜具有特异性的γ/δT细胞的寡克隆扩增。在非发炎的结肠中也存在相同的显性γ/δT细胞扩增。此外，外周γ/δTCR谱是寡克隆的，但与发炎的肠明显不同。因此，我们的结果不支持IBD中抗原特异性的γ/δT细胞的作用，并且外周血的显性γ/δT细胞不可能来自发炎的肠道。但是，在几例患者中，TCR-δ谱是高度多样化的，而在其他患者中，当比较发炎和未发炎的粘膜时，我们观察到了主要的γ/δT细胞克隆丢失。总之，这些变化表明，γ/δT细胞可能在IBD患者的一部分中起重要作用。

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