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首页> 外文期刊>American Journal of Physiology >Different alpha-adrenoceptors mediate migration of vascular smooth muscle cells and adventitial fibroblasts in vitro.
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Different alpha-adrenoceptors mediate migration of vascular smooth muscle cells and adventitial fibroblasts in vitro.

机译：不同的α-肾上腺素受体在体外介导血管平滑肌细胞和外膜成纤维细胞的迁移。

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摘要

Norepinephrine directly induces growth of the vascular wall, which may involve not only proliferation of smooth muscle cells (SMCs) and adventitial fibroblasts (AFBs) but also augmentation of their migration. To test this hypothesis, growth-arrested SMCs and AFBs from rat aorta were exposed to norepinephrine. Norepinephrine caused dose-dependent migration of both cell types that was dependent on chemotaxis. In contrast, platelet-derived growth factor (PDGF)-BB, used as a positive control, stimulated both chemotaxis and chemokinesis. Only alpha(1D)-adrenoceptors (AR) and alpha(2)-AR antagonists inhibited norepinephrine migration of SMCs, whereas norepinephrine migration of AFBs was only inhibited by alpha(1A)-AR and alpha(1B)-AR antagonists; beta-AR blockade was without effect. Norepinephrine and PDGF-BB were additive for AFB, but not SMC, migration. Stimulation of migration was reversed at high norepinephrine concentrations (10 microM); this inhibition was mediated by alpha(2)- and beta-ARs in AFBs butnot in SMCs. Thus norepinephrine induces migration of SMCs and AFBs via different alpha-ARs. This action may participate in wall remodeling and norepinephrine potentiation of injury-induced intimal lesion growth.
机译：去甲肾上腺素直接诱导血管壁的生长，这可能不仅涉及平滑肌细胞（SMCs）和外膜成纤维细胞（AFBs）的增殖，而且还包括其迁移的增加。为了验证该假设，将大鼠主动脉中生长停滞的SMC和AFB暴露于去甲肾上腺素。去甲肾上腺素引起依赖于趋化性的两种细胞的剂量依赖性迁移。相反，用作阳性对照的血小板衍生生长因子（PDGF）-BB刺激趋化性和趋化性。仅α（1D）-肾上腺素受体（AR）和α（2）-AR拮抗剂抑制SMC的去甲肾上腺素迁移，而AFB的去甲肾上腺素迁移仅受α（1A）-AR和α（1B）-AR拮抗剂抑制; β-AR封锁无效。去甲肾上腺素和PDGF-BB是AFB的添加剂，而不是SMC的迁移。去甲肾上腺素浓度高（10 microM）时，迁移的刺激作用相反。这种抑制作用是由AFB中的alpha（2）-和beta-AR介导的，而在SMC中则没有。因此，去甲肾上腺素通过不同的α-AR诱导SMC和AFB迁移。该作用可能参与壁重塑和去甲肾上腺素对损伤引起的内膜病变生长的增强作用。

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