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首页> 外文期刊>American Journal of Physiology >Blocking cerebrospinal fluid absorption through the cribriform plate increases resting intracranial pressure.
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Blocking cerebrospinal fluid absorption through the cribriform plate increases resting intracranial pressure.

机译：阻断通过筛状板吸收脑脊液会增加静息颅内压。

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摘要

Cerebrospinal fluid (CSF) drains through the cribriform plate (CP) in association with the olfactory nerves. From this location, CSF is absorbed into nasal mucosal lymphatics. Recent data suggest that this pathway plays an important role in global CSF transport in sheep. In this report, we tested the hypothesis that blocking CSF transport through this pathway would elevate resting intracranial pressure (ICP). ICP was measured continuously from the cisterna magna of sheep before and after CP obstruction in the same animal. To block CSF transport through the CP, an external ethmoidectomy was performed. The olfactory and adjacent mucosa were removed, and the bone surface was sealed with tissue glue. To restrict our analysis to the cranial CSF system, CSF transport into the spinal subarachnoid compartment was prevented with a ligature tightened around the thecal sac between C1 and C2. Sham surgical procedures had no significant effects, but in the experimental group CP obstruction elevated ICP significantly. Mean postobstruction steady-state pressures (18.0 +/- 3.8 cmH(2)O) were approximately double the preobstruction values (9.2 +/- 0.9 cmH(2)O). These data support the concept that the olfactory pathway represents a major site for CSF drainage.
机译：脑脊液（CSF）通过网状板（CP）排出，并伴有嗅觉神经。从这个位置，CSF被鼻粘膜淋巴管吸收。最新数据表明，该途径在绵羊的全球脑脊液运输中起重要作用。在本报告中，我们测试了以下假设：阻止脑脊液通过该途径的转运会升高静息颅内压（ICP）。在同一只动物的CP阻塞前后，从绵羊的水罐中连续测量ICP。为了阻止脑脊液通过CP的转运，需进行外部筛窦切除术。去除嗅觉和邻近的粘膜，并用组织胶密封骨表面。为了将我们的分析限制在颅脑脊液系统中，通过在C1和C2之间的囊囊周围绑紧绑扎物，可以防止脑脊液转运到脊柱蛛网膜下腔。假手术步骤无明显效果，但在实验组中，CP阻塞明显增加了ICP。平均阻塞后稳态压力（18.0 +/- 3.8 cmH（2）O）约为阻塞前的两倍（9.2 +/- 0.9 cmH（2）O）。这些数据支持了嗅觉途径代表脑脊液引流的主要部位的概念。

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