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首页> 外文期刊>American Journal of Physiology >Nicotinic acid adenine dinucleotide phosphate: a new intracellular second messenger?
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Nicotinic acid adenine dinucleotide phosphate: a new intracellular second messenger?

机译：烟酸腺嘌呤二核苷酸磷酸：新的细胞内第二信使？

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摘要

Nicotinic acid adenine dinucleotide phosphate (NAADP) is one of the most potent stimulators of intracellular Ca2+ release known to date. The role of the NAADP system in physiological processes is being extensively investigated at the present time. Exciting new discoveries in the last 5 years suggest that the NAADP-regulated system may have a significant role in intracellular Ca2+ signaling. The NAADP receptor and its associated Ca2+ pool have been hypothesized to be important in several physiological processes including fertilization, T cell activation, and pancreatic secretion. However, whether NAADP is a new second messenger or a tool for the discovery of a new Ca2+ channel is still an unanswered question.
机译：烟酸腺嘌呤二核苷酸磷酸酯（NAADP）是迄今为止已知的最有效的细胞内Ca2 +释放刺激剂之一。目前正在广泛研究NAADP系统在生理过程中的作用。过去5年中令人振奋的新发现表明，NAADP调控系统可能在细胞内Ca2 +信号传导中起重要作用。假设NAADP受体及其相关的Ca2 +库在包括受精，T细胞活化和胰腺分泌在内的几个生理过程中很重要。但是，NAADP是新的第二信使还是发现新的Ca2 +通道的工具仍然是一个悬而未决的问题。

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