• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Physiology >Synchronization of ventricular fibrillation with real-time feedback pacing: implication to low-energy defibrillation.
【24h】

Synchronization of ventricular fibrillation with real-time feedback pacing: implication to low-energy defibrillation.

机译：心室颤动与实时反馈起搏同步：对低能量除颤的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Wavefront synchronization is an important aspect preceding the termination of ventricular fibrillation (VF). We evaluated the defibrillation efficacy of a novel multisite pacing algorithm using optical recording-guided synchronized pacing (SyncP) in the excitable gaps. We compared the effects of SyncP with traditional overdrive pacing (ODP) at 90% of the VF cycle length (VFCL) and high-frequency pacing (HFP; 43-215 Hz) on spontaneous VF termination in isolated rabbit hearts. For SyncP, the pacing current was triggered by the activation of a reference site and was delivered when the optical potential of the pacing site was in an excitable gap. We measured VFCL and the spatial dispersion of VFCL (SDCL) from five points (3 points in the paced area and 2 points in the nonpaced area) and the distribution of phase singularities during the prepacing, pacing, and postpacing periods. The results showed that 1) the VF termination rate of SyncP (16.0%, n = 106) was higher than that of ODP (2.1%, n = 48, P < 0.01)or HFP (1.6%, n = 129, P < 0.0001); 2) energy consumption for SyncP (7.6 +/- 9.3 mJ) was significantly lower than that of ODP (14.0 +/- 14.8 mJ, P < 0.0001); and 3) SyncP, but not ODP or HFP, decreased SDCL in the paced area during the pacing (P < 0.01) and postpacing (P < 0.05) periods compared with the prepacing period. We conclude that SyncP is effective in inducing wavefront synchronization and is more effective at facilitating spontaneous VF termination than non-SyncP.
机译：波前同步是终止心室纤颤（VF）之前的重要方面。我们评估了在兴奋性间隙中使用光学记录引导同步起搏（SyncP）的新型多部位起搏算法的除颤效果。我们将SyncP与传统超速起搏（ODP）在VF周期长度（VFCL）的90％和高频起搏（HFP; 43-215 Hz）对离体兔心脏自发性VF终止的影响进行了比较。对于SyncP，起搏电流由参考部位的激活触发，并在起搏部位的光势处于可激发间隙时传递。我们在起搏，起搏和后起搏期间分别从五个点（起搏区域中的3个点和非起搏区域中的2个点）测量了VFCL和VFCL（SDCL）的空间色散，以及相位奇点的分布。结果表明：1）SyncP的VF终止率（16.0％，n = 106）高于ODP（2.1％，n = 48，P <0.01）或HFP（1.6％，n = 129，P <0.01） 0.0001）; 2）SyncP的能耗（7.6 +/- 9.3 mJ）显着低于ODP的能耗（14.0 +/- 14.8 mJ，P <0.0001）;和3）与起搏期间相比，在起搏（P <0.01）和起搏后（P <0.05）期间，SyncP而非ODP或HFP降低了起搏区域的SDCL。我们得出结论，与非SyncP相比，SyncP在诱导波前同步方面有效，并且在促进自发VF终止方面更有效。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号