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首页> 外文期刊>American Journal of Physiology >Expressions of adrenomedullin mRNA and protein in rats with hypobaric hypoxia-induced pulmonary hypertension.
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Expressions of adrenomedullin mRNA and protein in rats with hypobaric hypoxia-induced pulmonary hypertension.

机译：低压缺氧所致肺动脉高压大鼠肾上腺髓质素mRNA和蛋白的表达。

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摘要

Experimental pulmonary hypertension induced in a hypobaric hypoxic environment (HHE) is characterized by structural remodeling of the heart and pulmonary arteries. Adrenomedullin (AM) has diuretic, natriuretic, and hypotensive effects. To study the possible effects of HHE on the AM synthesis system, 150 male Wistar rats were housed in a chamber at the equivalent of a 5,500-m altitude level for 21 days. After 14 days of exposure to HHE, pulmonary arterial pressure (PAP) was significantly increased (compared with control rats). The plasma AM protein level was significantly increased on day 21 of exposure to HHE. In the right ventricle (RV), right atrium, and left atrium of the heart, the expressions of AM mRNA and protein were increased in the middle to late phase (5-21 days) of HHE, whereas in the brain and lung they were increased much earlier (0.5-5 days). In situ hybridization and immunohistochemistry showed AM mRNA and protein staining to be more intense in the RV in animals in the middle to late phase of HHE exposure than in the controls. During HHE, these changes in AM synthesis, which occurred strongly in the RV, occurred alongside the increase in PAP. Conceivably, AM may play a role in modulating pulmonary hypertension in HHE.
机译：在低压缺氧环境（HHE）中诱发的实验性肺动脉高压的特征是心脏和肺动脉的结构重塑。肾上腺髓质素（AM）具有利尿，利钠和降压作用。为了研究HHE对AM合成系统的可能影响，将150只雄性Wistar大鼠放在相当于5500米高度的小室中放置21天。暴露于HHE 14天后，肺动脉压（PAP）明显升高（与对照组相比）。暴露于HHE的第21天血浆AM蛋白水平显着增加。在心脏的右心室（RV），右心房和左心房中，AM mRNA和蛋白的表达在HHE的中晚期（5-21天）增加，而在脑和肺中，增加得更早（0.5-5天）。原位杂交和免疫组化显示，在HHE暴露的中晚期，动物的RV中AM mRNA和蛋白染色比对照组更强烈。在HHE期间，AM合成中的这些变化在RV中强烈发生，与PAP的增加同时发生。可以想象，AM可能在调节HHE中的肺动脉高压中起作用。

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