Antimacrophage chemokine treatment prevents neutrophil and macrophage influx in hyperoxia-exposed newborn rat lung

Michael A. Vozzelli; S. Nicholas Mason; Mary H. Whorton; Richard L. Auten

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Antimacrophage chemokine treatment prevents neutrophil and macrophage influx in hyperoxia-exposed newborn rat lung

机译：抗巨噬细胞趋化因子治疗可防止高氧暴露新生大鼠肺中的中性粒细胞和巨噬细胞流入

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Macrophage-derived cytokines may provoke the inflammatory response in lung injury. Because macrophage influx is a prominent feature of the cellular inflammatory response accompanying the development of bronchopulmonary dysplasia, we hypothesized that blocking macrophage influx would reduce overall cellular influx and oxidative damage. Newborn rats were exposed at birth to 95% O_2 or air for 1 wk, and hyperoxia-exposed pups were injected with anti-monocyte chemoattractant protein-1 (MCP-1) or IgG control on days 3-5. MCP-1 was increased in bronchoalveolar lavage fluid and in histological sections from the 95% O_2-exposed, IgG-injected pups compared with air-exposed controls.

机译：巨噬细胞源性细胞因子可能在肺损伤中引起炎症反应。由于巨噬细胞流入是伴随支气管肺发育不良发展的细胞炎症反应的突出特征，因此我们假设阻断巨噬细胞流入将减少总体细胞流入和氧化损伤。新生大鼠在出生时暴露于95％O_2或空气中1周，并在3-5天向高氧暴露的幼崽注射抗单核细胞趋化蛋白1（MCP-1）或IgG对照。与暴露于空气的对照组相比，暴露于95％的O_2的，注射IgG的幼犬的支气管肺泡灌洗液和组织学切片中的MCP-1含量增加。

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《American Journal of Physiology》 |2004年第1期|共6页
作者
Michael A. Vozzelli; S. Nicholas Mason; Mary H. Whorton; Richard L. Auten;
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1. Antimacrophage chemokine treatment prevents neutrophil and macrophage influx in hyperoxia-exposed newborn rat lung [J] . Michael A. Vozzelli, S. Nicholas Mason, Mary H. Whorton, American Journal of Physiology . 2004,第3aPta1期

机译：抗巨噬细胞趋化因子治疗可防止高氧暴露新生大鼠肺中的中性粒细胞和巨噬细胞流入
2. Nonpeptide CXCR2 Antagonist Prevents Neutrophil Accumulation in Hyperoxia-Exposed Newborn Rats [J] . Richard L. Auten, Rlcardo M. Rlchardson, John R. White, The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2001,第1期

机译：非肽CXCR2拮抗剂可防止高氧暴露新生大鼠中性粒细胞积累。
3. Neutrophil elastase-induced elastin degradation mediates macrophage influx and lung injury in 60% O2-exposed neonatal rats [J] . Azhar Masood, Man Yi, Rosetta Belcastro American Journal of Physiology . 2015,第1aPta1期

机译：中性粒细胞弹性蛋白酶诱导的弹性蛋白降解在60％O2暴露的新生大鼠中介导巨噬细胞流入和肺损伤
4. V81~+ gammadelta T cells producing CC chemokines may bridge a gap between neutrophils and macrophages in innate immunity during Escherichia coli infection in mice [C] . Y. Yoshikai, T. Tagawa, K. Shibata, Uehara Memorial Foundation Symposium on the Innate Immune System . 2005

机译：产生CC趋化因子的V81〜+γ肠杆菌T细胞可以在小鼠大肠杆菌感染期间弥合中性粒细胞和巨噬细胞之间的间隙和巨噬细胞
5. Recruitment of neutrophils into lung by CXC chemokines. [D] . Merry, Andrew Clive. 2003

机译：CXC趋化因子将中性粒细胞招募入肺。
6. Streptococcal M1 Protein Triggers Farnesyltransferase-Dependent Formation of CXC Chemokines in Alveolar Macrophages and Neutrophil Infiltration of the Lungs [O] . Songen Zhang, Milladur Rahman, Su Zhang, 2012

机译：链球菌M1蛋白触发肺泡巨噬细胞中CXC趋化因子的法尼基转移酶依赖性形成和肺中性粒细胞浸润。
7. Blocking Neutrophil Influx Reduces DNA Damage in Hyperoxia-Exposed Newborn Rat Lung [O] . Richard L. Auten, Mary H. Whorton, S. Nicholas Mason 2013

机译：阻断中性粒细胞流入减少高氧暴露的新生大鼠肺部DNa损伤
8. Reduction of Neutrophil Influx Diminishes Lung Injury and Mortality Following Phosgene Inhalation. [R] . Ghio, A. J., Kennedy, T. P., Hatch, G. E., 1992

机译：减少中性粒细胞流入可减少光气吸入后肺损伤和死亡率。

Antimacrophage chemokine treatment prevents neutrophil and macrophage influx in hyperoxia-exposed newborn rat lung

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