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首页> 外文期刊>American Journal of Physiology >Endogenous calcitonin gene-related peptide modulates tachycardiac but not bradycardiac baroreflex in rats.
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Endogenous calcitonin gene-related peptide modulates tachycardiac but not bradycardiac baroreflex in rats.

机译：内源性降钙素基因相关肽可调节大鼠的心动过速而不是心动过缓的压力反射。

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摘要

Effects of intracisternally administered human calcitonin gene-related peptide (8-37) [hCGRP-(8-37)], an antagonist, and hCGRP, an agonist of the CGRP receptor in the rat central nervous system, on baroreflex sensitivity (BRS) were studied in conscious male rats. Each rat sequentially received intracisternally injected 0.9% saline and then hCGRP-(8-37) at doses of 1, 2.5, and 5 nmol in a volume of 10 microliters at an interval of 15 min. Five minutes after each injection, sodium nitroprusside (SNP, 10 micrograms/kg) or phenylephrine hydrochloride (PE, 2 micrograms/kg) was intravenously administered to induce reflex tachycardia or bradycardia, respectively. Intracisternally administered hCGRP-(8-37) increased BRS of the reflex tachycardia induced by SNP in a dose-related manner but did not change the BRS after PE. Intracisternally injected hCGRP significantly decreased the BRS after SNP. The lowering effect of hCGRP on BRS after SNP was inhibited by hCGRP-(8-37) injected before hCGRP. These results suggest that endogenous CGRP in the lower brain stem is selectively involved in the tachycardiac but not the bradycardiac baroreflex and modulates the baroreflex in an inhibitory rather than facilitatory fashion.
机译：颅内给药人降钙素基因相关肽（8-37）[hCGRP-（8-37）]（拮抗剂）和hCGRP（大鼠CGRP受体在大鼠中枢神经系统中的激动剂）对压力反射敏感性（BRS）的影响在有意识的雄性大鼠中进行了研究。每只大鼠在15分钟的间隔内依次接受10升体积的1、2.5和5 nmol剂量的脑池内注射0.9％盐水，然后接受hCGRP-（8-37）。每次注射五分钟后，分别静脉注射硝普钠（SNP，10微克/ kg）或盐酸去氧肾上腺素（PE，2微克/ kg），以诱发反射性心动过速或心动过缓。颅内给予hCGRP-（8-37）以剂量相关的方式增加了SNP引起的反射性心动过速的BRS，但在PE后并未改变BRS。颅内注射hCGRP显着降低了SNP后的BRS。 hCGRP降低SNP后BRS的作用被hCGRP之前注射的hCGRP-（8-37）抑制。这些结果表明，下脑干中的内源性CGRP选择性地参与了心动过速而不是心动过缓的压力感受器反射，并且以抑制而非促进的方式调节压力感受器反射。

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