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首页> 外文期刊>American Journal of Physiology >Effects of age, gender, and blood pressure on myogenic responses of mesenteric arteries from C57BL/6 mice.
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Effects of age, gender, and blood pressure on myogenic responses of mesenteric arteries from C57BL/6 mice.

机译：年龄，性别和血压对C57BL / 6小鼠肠系膜动脉成肌反应的影响。

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摘要

The myogenic response (MR) may represent an important physiological parameter underlying arterial blood pressure (BP). We studied the effects of age, gender, and BP on the MR of mesenteric arteries from 8- to 52-wk-old mice. Increasing age and BP are associated with an increase in the perfusion pressure at which tone develops (myogenic set point). An inverse correlation exists between age and extent (magnitude) of the MR in male (r(2) = 0.93, P = 0.0087) and female mice (r(2) = 0.90, P = 0.013) as well as between BP and extent of the MR in male (r(2) = 0.96, P = 0.0036) and female (r(2) = 0.90, P = 0.014) mice. In contrast, the strength of the MR (slope of active diameter-pressure relationship) and phenylephrine-mediated constriction did not differ among these groups. Although gender had no effect on MR at any perfusion pressure or age, only male mice showed significant salt-induced hypertension and an associated increase in the set point and reduction in the extent of the MR. The set point and extent of the MR is linked to the in vivo pressure during development and experimental hypertension.
机译：肌源性反应（MR）可能代表动脉血压（BP）的重要生理参数。我们研究了年龄，性别和血压对8至52周龄小鼠肠系膜动脉MR的影响。年龄的增长和血压的升高与声调发展的灌注压力的增加有关（肌原性设定点）。雄性（r（2）= 0.93，P = 0.0087）和雌性小鼠（r（2）= 0.90，P = 0.013）的MR的年龄与程度（大小）之间存在负相关，并且BP与程度之间存在负相关雄性（r（2）= 0.96，P = 0.0036）和雌性（r（2）= 0.90，P = 0.014）小鼠的MR值。相反，在这些组中，MR的强度（活动直径-压力关系的斜率）和去氧肾上腺素介导的收缩没有差异。尽管性别在任何灌注压力或年龄下对MR均无影响，但只有雄性小鼠表现出明显的盐诱导性高血压，以及相关的设定值升高和MR程度降低。 MR的设定点和程度与发育和实验性高血压期间的体内压力有关。

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