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首页> 外文期刊>American Journal of Physiology >Has HGF met other partners? Met-independent epithelial morphogenesis induced by HGF.Focus on 'Hepatocyte growth factor induces MDCK cell morphogenesis without causing loss of tight junction functional integrity'
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Has HGF met other partners? Met-independent epithelial morphogenesis induced by HGF.Focus on 'Hepatocyte growth factor induces MDCK cell morphogenesis without causing loss of tight junction functional integrity'

机译：HGF是否见过其他合作伙伴？ HGF诱导的不依赖大都会的上皮形态发生。关注“肝细胞生长因子诱导MDCK细胞形态发生而不会引起紧密连接功能完整性的丧失”

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摘要

POLARIZED EPITHELIAL CELLS line the majority of vertebrate organs (including the urinary, digestive, and respiratory tracts), where they are responsible for life-sustaining vectorial transport and barrier functions. Morphogenesis of the epithelial cell phenotype is a complex phenomenon, and several decades of pioneering multidisciplinary studies have now begun to yield important clues toward our understanding of this process. Developmental and molecular biological investigations have identified critical growth and transcription factors that direct the biogenesis of epithelial organs. Concurrently, cell biological studies of epithelia cultured on two-dimensional filter supports or within three-dimensional extracellular matrix (ECM) systems have provided us with novel insights into the mechanisms by which these factors orchestrate epithelial morphogenesis. These approaches have recently led to the proposal of a two-phase working hypothesis (8, 12).
机译：极化的上皮细胞排列在大多数脊椎动物器官（包括泌尿，消化道和呼吸道）中，它们负责维持生命的矢量运输和屏障功能。上皮细胞表型的形态发生是一个复杂的现象，几十年的开创性多学科研究现已开始为我们对这一过程的理解提供重要线索。发展和分子生物学研究已经确定了指导上皮器官生物发生的关键生长和转录因子。同时，在二维过滤器支持物上或三维细胞外基质（ECM）系统中培养的上皮细胞生物学研究为我们提供了新的见解，探讨了这些因素协调上皮形态发生的机制。这些方法最近导致提出了两阶段工作假设的提议（8、12）。

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