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首页> 外文期刊>American Journal of Physiology >Osmoregulatory control of renal sodium excretion after sodium loading in humans.
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Osmoregulatory control of renal sodium excretion after sodium loading in humans.

机译：人体中钠负荷后对肾脏钠排泄的渗透调节控制。

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摘要

The hypothesis that renal sodium handling is controlled by changes in plasma sodium concentration was tested in seated volunteers. A standard salt load (3.08 mmol/kg body wt over 120 min) was administered as 0.9% saline (Isot) or as 5% saline (Hypr) after 4 days of constant sodium intake of 75 (LoNa+) or 300 mmol/day (HiNa+). Hypr increased plasma sodium by approximately 4 mmol/l but increased plasma volume and central venous pressure significantly less than Isot irrespective of diet. After LoNa+, Hypr induced a smaller increase in sodium excretion than Isot (48 +/- 8 vs. 110 +/- 17 micromol/min). However, after HiNa+ the corresponding natriureses were identical (135 +/- 33 vs. 139 +/- 39 micromol/min), despite significant difference between the increases in central venous pressure. Decreases in plasma ANG II concentrations of 23-52% were inversely related to sodium excretion. Mean arterial pressure, plasma oxytocin and atrial natriuretic peptide concentrations, and urinary excretion rates of endothelin-1 and urodilatin remained unchanged. The results indicate that an increase in plasma sodium may contribute to the natriuresis of salt loading when salt intake is high, supporting the hypothesis that osmostimulated natriuresis is dependent on sodium balance in normal seated humans.
机译：在就座志愿者中测试了肾钠处理受血浆钠浓度变化控制的假设。在持续摄入钠75（LoNa +）或300 mmol /天4天后，标准盐负荷（120分钟内3.08 mmol / kg体重，以0.9％盐水（Isot）或5％盐水（Hypr）施用） HiNa +）。 Hypr使血浆钠含量增加约4 mmol / l，但与饮食无关，血浆体积和中心静脉压的增加明显少于Isot。在LoNa +之后，Hypr引起的钠排泄增加量比Isot小（48 +/- 8对110 +/- 17微摩尔/分钟）。然而，尽管中心静脉压升高之间存在显着差异，但在HiNa +注射后，相应的利尿钠相同（135 +/- 33 vs. 139 +/- 39 micromol / min）。血浆ANG II浓度降低23-52％与钠排泄成反比。平均动脉压，血浆催产素和心房利钠肽浓度以及内皮素1和urodilatin的尿排泄率保持不变。结果表明，当盐摄入量很高时，血浆钠的增加可能有助于盐负荷中的钠利尿，支持以下假设：在正常就座的人群中，渗透压钠利尿依赖于钠平衡。

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