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首页> 外文期刊>American Journal of Physiology >Regulation mode of evaporative cooling underlying a strategy of the heat-tolerant FOK rat for enduring ambient heat.
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Regulation mode of evaporative cooling underlying a strategy of the heat-tolerant FOK rat for enduring ambient heat.

机译：蒸发冷却的调节模式是耐热FOK大鼠耐环境热量的策略的基础。

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Compared with other rat strains, the inbred FOK rat is extremely heat tolerant. This increased heat tolerance is due largely to the animal's enhanced saliva spreading abilities. The aims of the present study were to 1) quantify the heat tolerance capacity of FOK rats and 2) determine the regulatory mode of the enhanced salivary cooling in these animals. Various strains of rats were acutely exposed to heat. In the heat-intolerant strains, saliva spreading was insufficient and the core temperature (Tc) rose rapidly. In contrast, FOK rats maintained an elevated Tc plateau (39.5 +/- 0.7 degrees C) for 5-6 h over a wide range of ambient temperatures (Ta) (37.5-42.5 degrees C). In hot environments the FOK rats secreted copious amounts of saliva and spread it over more than the entire ventral body surface. FOK rats had a low Tc threshold for salivation, and the salivation rate increased linearly in proportion to the Tc deviation from the threshold. No strain difference or temperature effect was observed in the saliva secretion rate from in vitro submandibular glands perfused by sufficient doses of ACh. These results suggest that 1) the ability of FOK rats to maintain a moderate steady-state hyperthermia (39.5 +/- 0.7 degrees C) over a wide Ta range is enabled by a lowered threshold Tc for salivation and functional negative-feedback control of saliva secretion and 2) strain differences in ability to endure heat stress are mainly attributable to changes in the thermoregulatory control system rather than altered secretory abilities of the salivary glands.
机译：与其他大鼠品系相比，近交FOK大鼠具有极高的耐热性。这种提高的耐热性很大程度上是由于动物增强了唾液传播能力。本研究的目的是：1）量化FOK大鼠的耐热能力，以及2）确定这些动物中唾液冷却增强的调节模式。各种大鼠急性暴露于热。在不耐热的菌株中，唾液扩散不足，核心温度（Tc）迅速上升。相比之下，FOK大鼠在较宽的环境温度（Ta）（37.5-42.5摄氏度）范围内保持升高的Tc平稳期（39.5 +/- 0.7摄氏度）5-6小时。在炎热的环境中，FOK大鼠分泌大量唾液，并将其散布在整个腹侧体表上。 FOK大鼠的唾液Tc阈值较低，唾液分泌速率与Tc偏离阈值成正比，呈线性关系。在用足够剂量的ACh灌注的下颌下腺的唾液中，没有观察到应变差异或温度效应。这些结果表明1）通过降低唾液的阈值Tc和唾液的功能性负反馈控制，可以使FOK大鼠在较宽的Ta范围内维持中等水平的稳态高温（39.5 +/- 0.7摄氏度）的能力分泌和2）应变承受热应激能力的差异主要归因于温度调节控制系统的变化，而不是唾液腺分泌能力的改变。

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