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首页> 外文期刊>American Journal of Physiology >Dissociation between volume blood flow and laser-Doppler signal from rat muscle during changes in vascular tone.
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Dissociation between volume blood flow and laser-Doppler signal from rat muscle during changes in vascular tone.

机译：在血管紧张度变化期间，体积血流量与来自大鼠肌肉的激光多普勒信号之间的分离。

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Although the laser-Doppler flowmetry (LDF) signal from skeletal muscle has been shown to provide a good measure of blood flow under some conditions, its behavior during administration of vasoactive substances has never been addressed. The aims of this study were to compare 1) changes in LDF signal with those in total muscle blood flow measured with radioactive microspheres after ganglionic blockade (chlorisondamine) and during administration of angiotensin II (ANG II), phenylephrine (PE), and isoproterenol (Iso) and 2) changes in vascular resistance estimated by the two techniques. The LDF signal from the biceps femoris muscle was investigated in anesthetized male Wistar rats. Ganglionic blockade led to a significant (P < 0.05) fall in mean arterial pressure (MAP) [medians (lower, upper quartiles): 78 (72, 83) vs. 127 (114, 138) mmHg under basal conditions], muscle blood flow (MBF, microsphere technique; 61%), and the LDF signal (29%). Muscle vascular resistance (MVR = MAP/MBF) was increased (64%, P < 0.05), but vascular resistance estimated as MAP/LDF signal (MVRLDF) was unchanged. During ANG II and PE infusions, MAP rose (P < 0.05) to 178 (155, 194) and 127 (124, 142) mmHg, respectively; MBF did not change compared with the preinfusion (postganglionic blockade) level and remained significantly (P < 0.05) lower than baseline, whereas the LDF signal increased up to a level not different from baseline. MVR rose and was significantly (P < 0.05) higher than baseline, whereas MVRLDF did not differ significantly from baseline. During Iso infusion, MAP fell [58 (56, 60) vs. 94 (92, 102) mmHg, P < 0.05], the LDF signal was reduced (49%, P < 0.05) despite a large increase in MBF (139%, P < 0.05), and MVR fell (74%, P < 0.05), whereas MVRLDF did not change vs. preinfusion level. Our results suggest that 1) changes in the LDF signal from muscle may not correlate with changes in total muscle blood flow measured by the microsphere technique during infusion of vasoactive substances and 2) the use of LDF data for estimation of MVR during changes in vascular tone in rat skeletal muscle is probably not appropriate.
机译：尽管已显示骨骼肌的激光多普勒血流仪（LDF）信号在某些情况下可很好地测量血流，但从未解决其在血管活性物质给药过程中的行为。这项研究的目的是比较1）LDF信号的变化与神经节阻滞（氯代二胺）以及血管紧张素II（ANG II），去氧肾上腺素（PE）和异丙肾上腺素（ Iso）和2）通过两种技术估算的血管阻力变化。在麻醉的雄性Wistar大鼠中研究了股二头肌的LDF信号。神经节阻滞导致平均动脉压（MAP）显着下降（P <0.05）[中位值（下，上四分位数）：在基础情况下为78（72，83）vs. 127（114，138）mmHg]，肌肉血液流量（MBF，微球技术; 61％）和LDF信号（29％）。肌肉血管阻力（MVR = MAP / MBF）增加（64％，P <0.05），但以MAP / LDF信号（MVRLDF）估算的血管阻力不变。在ANG II和PE输注期间，MAP升高（P <0.05）分别达到178（155，194）和127（124，142）mmHg（P <0.05）。与输注前（神经节后阻滞）水平相比，MBF不变，并且仍显着低于基线（P <0.05），而LDF信号升高至与基线无差异的水平。 MVR升高并且显着高于基线（P <0.05），而MVRLDF与基线无显着差异。在Iso输注期间，尽管MBF大幅增加（139％），但MAP下降[58（56，60）vs. 94（92，102）mmHg，P <0.05]，LDF信号降低（49％，P <0.05）。 ，P <0.05）和MVR下降（74％，P <0.05），而MVRLDF与输注前水平相比没有变化。我们的结果表明：1）肌肉中LDF信号的变化可能与微血管技术在输注血管活性物质过程中测得的总肌肉血流变化不相关; 2）在血管紧张度变化期间使用LDF数据估算MVR在大鼠骨骼肌中大概是不合适的。

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