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首页> 外文期刊>American Journal of Physiology >Step baroreflex response in awake patients undergoing carotid surgery: time- and frequency-domain analysis.
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Step baroreflex response in awake patients undergoing carotid surgery: time- and frequency-domain analysis.

机译：接受颈动脉手术的清醒患者的逐步压力反射反应：时域和频域分析。

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摘要

Step baroreceptor stimulation can provide an insight into the baroreflex control mechanism, yet this has never been done in humans. During carotid surgery under regional anesthesia, a step increase in baroreceptor stimulation occurs at carotid declamping immediately after removal of the intra-arterial atheromatous plaque. In 10 patients, the R-R interval and systolic and diastolic blood pressures (BP) were continuously recorded, and signals obtained within the time window from 10 min before until 10 min after carotid declamping were analyzed. Mean +/- SD time signals, power spectra, and transfer and coherence functions before and after declamping were calculated. Immediately after carotid declamping, both heart rate (HR) and BP declined in an exponential-like manner lasting 10.3 +/- 5.9 min, and their power spectra increased in the entire frequency range. Transfer function magnitude and coherence functions between BP and HR increased predominantly in the midfrequency region (approximately 0.1 Hz), with no change in phase function. Thus, in carotid endarterectomy patients, step increase in baroreceptor gain elicits a prolonged decline in HR and BP. Frequency analyses support the notion that the baroreflex control mechanism generates the midfrequency HR and BP variability, although other frequency regions are also affected.
机译：逐步压力感受器刺激可以提供对压力反射控制机制的深入了解，但是这在人类中从未实现。在区域麻醉下进行颈动脉手术期间，在去除动脉内动脉粥样斑块后立即在颈动脉松动时发生压力感受器刺激的逐步增加。在10例患者中，连续记录R-R间隔以及收缩压和舒张压（BP），并分析在从时间间隔内（从颈动脉去钳前10分钟到术后10分钟）获得的信号。计算了去钳位前​​后的平均+/- SD时间信号，功率谱以及传递和相干函数。颈动脉放松后，心率（HR）和血压立即以指数方式下降，持续10.3 +/- 5.9分钟，并且它们的功率谱在整个频率范围内均增加。 BP和HR之间的传递函数幅度和相干函数主要在中频区域（大约0.1 Hz）增加，而相位函数没有变化。因此，在颈动脉内膜切除术患者中，压力感受器增益的逐步增加会引起HR和BP的持续下降。频率分析支持以下观点：压力反射控制机制会产生中频HR和BP变异性，尽管其他频率区域也会受到影响。

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