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首页> 外文期刊>American Journal of Physiology >Reduced osmotically inactive Na storage capacity and hypertension in the Dahl model.
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Reduced osmotically inactive Na storage capacity and hypertension in the Dahl model.

机译：在Dahl模型中减少了渗透活性的Na储存能力和高血压。

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摘要

Recent evidence suggested that Na can be stored in an osmotically inactive form. We investigated whether osmotically inactive Na storage is reduced in a rat model of salt-sensitive (SS) hypertension. SS and salt-resistant (SR) Dahl-Rapp rats as well as Sprague-Dawley (SD) rats were fed a high (8%)- or low (0.1%)-NaCl diet for 4 wk (n = 10/group). Mean arterial pressure (MAP) was measured at the end of the experiment. Wet and dry weights, water content, total body Na (TBS), and bone Na content were measured by dessication and dry ashing. MAP was higher in both Dahl strains than in SD rats. In SS rats, 8% NaCl led to Na accumulation, water retention, and hypertension due to impaired renal Na excretion. There was no dietary-induced Na retention in SR and SD rats. TBS was variable; nevertheless, TBS was significantly correlated with body water and MAP in all strains. However, the extent of Na-associated volume and MAP increases was strain specific. Osmotically inactive Na in SD rats was threefold higher than in SS and SR rats. Both SS and SR Dahl rat strains displayed reduced osmotically inactive Na storage capacity compared with SD controls. A predisposition to fluid accumulation and high blood pressure results from this alteration. Additional factors, including impaired renal Na excretion, probably contribute to hypertension in SS rats. Our results draw attention to the role of osmotically inactive Na storage.
机译：最近的证据表明，Na可以以渗透失活的形式储存。我们研究了盐敏感性（SS）高血压大鼠模型中渗透活性钠的储存是否减少。对SS和耐盐（SR）的Dahl-Rapp大鼠以及Sprague-Dawley（SD）的大鼠喂食高（8％）-或低（0.1％）-NaCl饮食4周（n = 10 /组） 。在实验结束时测量平均动脉压（MAP）。通过干燥和灰化来测量干重，水含量，全身Na（TBS）和骨Na含量。两种Dahl品系中的MAP均高于SD大鼠。在SS大鼠中，由于肾Na排泄受损，8％的NaCl导致Na积累，水retention留和高血压。在SR和SD大鼠中没有饮食引起的Na retention留。 TBS是可变的;然而，在所有菌株中，TBS与体内水和MAP显着相关。然而，Na相关体积和MAP增加的程度是菌株特异性的。 SD大鼠的渗透活性低的Na比SS和SR大鼠高三倍。与SD对照相比，SS和SR Dahl大鼠品系均显示出减少的渗透活性Na储存能力。这种改变会导致体液积聚和高血压。其他因素，包括肾Na排泄受损，可能导致SS大鼠高血压。我们的研究结果引起了人们对渗透活性钠存储作用的关注。

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