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首页> 外文期刊>American Journal of Physiology >Balance between myogenic, flow-dependent, and metabolic flow control in coronary arterial tree: a model study.
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Balance between myogenic, flow-dependent, and metabolic flow control in coronary arterial tree: a model study.

机译：冠状动脉树中肌源性，流量依赖性和代谢流量控制之间的平衡：模型研究。

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摘要

Myogenic response, flow-dependent dilation, and direct metabolic control are important mechanisms controlling coronary flow. A model was developed to study how these control mechanisms interact at different locations in the arteriolar tree and to evaluate their contribution to autoregulatory and metabolic flow control. The model consists of 10 resistance compartments in series, each representing parallel vessel units, with their diameters determined by tone depending on either flow and pressure [flow-dependent tone reduction factor (TRF(flow)) x Tone(myo)] or directly on metabolic factors (Tone(meta)). The pressure-Tone(myo) and flow-TRF(flow) relations depend on the vessel size obtained from interpolation of data on isolated vessels. Flow-dependent dilation diminishes autoregulatory properties compared with pressure-flow lines obtained from vessels solely influenced by Tone(myo). By applying Tone(meta) to the four distal compartments, the autoregulatory properties are restored and tone is equally distributed over the compartments. Also, metabolic control and blockage of nitric oxide are simulated. We conclude that a balance is required between the flow-dependent properties upstream and the constrictive metabolic properties downstream. Myogenic response contributes significantly to flow regulation.
机译：肌源性反应，血流依赖性扩张和直接代谢控制是控制冠状动脉血流的重要机制。开发了一个模型来研究这些控制机制如何在小动脉树的不同位置相互作用，并评估它们对自动调节和代谢流量控制的作用。该模型由10个串联的阻力室组成，每个阻力室代表平行的容器单元，其直径由音调决定，该音调取决于流量和压力[取决于流量的音调降低系数（TRF（flow））x Tone（myo）]或直接位于代谢因子（Tone（meta））。压力-音调（myo）和流量-TRF（流量）关系取决于从隔离的容器上数据插值获得的容器尺寸。与从单独受Tone（myo）影响的血管中获得的压力流线相比，与流量有关的扩张减弱了自动调节性能。通过将Tone（meta）应用于四个远端隔室，可恢复自动调节特性，并且在整个隔室中均匀分配音调。此外，模拟了代谢控制和一氧化氮的阻滞。我们得出结论，需要在上游的流量依赖性特性和下游的收缩代谢特性之间取得平衡。肌源性反应显着促进流量调节。

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