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首页> 外文期刊>American Journal of Physiology >Static filling pressure in patients during induced ventricular fibrillation.
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Static filling pressure in patients during induced ventricular fibrillation.

机译：诱发心室纤颤期间患者的静态充盈压。

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摘要

The static pressure resulting after the cessation of flow is thought to reflect the filling of the cardiovascular system. In the past, static filling pressures or mean circulatory filling pressures have only been reported in experimental animals and in human corpses, respectively. We investigated arterial and central venous pressures in supine, anesthetized humans with longer fibrillation/defibrillation sequences (FDSs) during cardioverter/defibrillator implantation. In 82 patients, the average number of FDSs was 4 +/- 2 (mean +/- SD), and their duration was 13 +/- 2 s. In a total of 323 FDSs, arterial blood pressure decreased with a time constant of 2.9 +/- 1.0 s from 77.5 +/- 34.4 to 24.2 +/- 5.3 mmHg. Central venous pressure increased with a time constant of 3.6 +/- 1.3 s from 7.5 +/- 5.2 to 11.0 +/- 5.4 mmHg (36 points, 141 FDS). The average arteriocentral venous blood pressure difference remained at 13.2 +/- 6.2 mmHg. Although it slowly decreased, the pressure difference persisted even with FDSs lasting 20 s. Lack of true equilibrium pressure could possibly be due to a waterfall mechanism. However, waterfalls were identified neither between the left ventricle and large arteries nor at the level of the diaphragm in supine patients. We therefore suggest that static filling pressures/mean circulatory pressures can only be directly assessed if the time after termination of cardiac pumping is adequate, i.e., >20 s. For humans, such times are beyond ethical options.
机译：停止流动后产生的静压被认为反映了心血管系统的充盈。过去，仅在实验动物和人体中分别报道了静态填充压力或平均循环填充压力。我们调查了在心脏复律器/除颤器植入过程中具有较长的纤颤/除颤序列（FDS）的仰卧麻醉的人的动脉和中央静脉压力。在82例患者中，FDS的平均数量为4 +/- 2（平均+/- SD），持续时间为13 +/- 2 s。在总共323个FDS中，动脉血压以2.9 +/- 1.0 s的时间常数从77.5 +/- 34.4毫米降低到24.2 +/- 5.3毫米汞柱。中心静脉压力以3.6 +/- 1.3 s的时间常数从7.5 +/- 5.2增加到11.0 +/- 5.4 mmHg（36点，141 FDS）。平均动静脉压力差保持在13.2 +/- 6.2 mmHg。尽管它缓慢降低，但即使FDS持续20 s，压力差仍然存在。缺乏真正的平衡压力可能是由于瀑布机制所致。但是，仰卧患者既未在左心室与大动脉之间也未发现瀑布。因此，我们建议仅在终止心脏泵送后的时间足够长（即> 20 s）时才能直接评估静态填充压力/平均循环压力。对于人类而言，这样的时代已超出道德选择。

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