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首页> 外文期刊>American Journal of Physiology >Regulation of hepatic glutamine metabolism during exercise in the dog.
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Regulation of hepatic glutamine metabolism during exercise in the dog.

机译：狗在运动过程中肝脏谷氨酰胺代谢的调节。

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The goal of this study was to determine how liver glutamine (Gln) metabolism adapts to acute exercise in the 18-h-fasted dogs (n = 7) and in dogs that were glycogen depleted by a 42-h fast (n = 8). For this purpose, sampling (carotid artery, portal vein, and hepatic vein) and infusion (vena cava) catheters and Doppler flow probes (portal vein, hepatic artery) were implanted under general anesthesia. At least 16 days later an experiment, consisting of a 120-min equilibration period, a 30-min basal sampling period, and a 150-min exercise period was performed. At the start of the equilibration period, a constant-rate infusion of [5-15N]Gln was initiated. Arterial Gln flux was determined by isotope dilution. Gut and liver Gln release into and uptake from the blood were calculated by combining stable isotopic and arteriovenous difference methods. The results of this study show that 1) in the 18-h-fasted dog, approximately 10% and approximately 35% of the basal Gln appearance in arterial blood is due to Gln release from the gut and liver, respectively, whereas approximately 30% and approximately 25% of the basal Gln disappearance is due to removal by these tissues; 2) extending the fast to 42 h does not affect basal arterial Gln flux or the contribution of the gut to arterial Gln fluxes but decreases hepatic Gln release, causing a greater retention of gluconeogenic carbon by the liver; 3) moderate-intensity exercise increases hepatic Gln removal from the blood regardless of fast duration but does not affect the hepatic release of Gln; and 4) Gln plays an important role in channeling nitrogen into the ureagenic pathway in the basal state, and this role is increased by approximately 80% in response to exercise. These studies illustrate the quantitative importance of the splanchnic bed contribution to arterial Gln flux during exercise and the ability of the liver to acutely adapt to changes in metabolic requirements induced by the combined effects of fasting and exercise.
机译：这项研究的目的是确定禁食18 h的狗（n = 7）和糖原消耗了42 h的狗（n = 8）的肝谷氨酰胺（Gln）代谢如何适应急性运动。 。为此，在全身麻醉下植入取样（颈动脉，门静脉和肝静脉）和输液（静脉）导管和多普勒血流探头（门静脉，肝动脉）。至少16天后，进行了一个实验，包括120分钟的平衡时间，30分钟的基础采样时间和150分钟的运动时间。在平衡期开始时，开始恒速输注[5-15N] Gln。通过同位素稀释确定动脉Gln通量。通过结合稳定的同位素和动静脉差异法计算肠道和肝脏Gln在血液中的释放和摄取。这项研究的结果表明：1）在禁食18小时的狗中，动脉血中基础Gln出现的大约10％和大约35％分别是由于Gln从肠道和肝脏释放引起的，而大约30％大约25％的基础Gln消失是由于这些组织的去除所致; 2）将禁食时间延长至42 h不会影响基底动脉Gln通量或肠道对动脉Gln通量的贡献，但会降低肝Gln的释放，从而导致肝脏中糖原异生碳的保留更大; 3）中等强度的运动会增加肝脏从血液中清除Gln的能力，而不管其持续时间长短，但不会影响肝脏Gln的释放; （4）Gln在基础状态下将氮引导到尿素生成途径中起着重要作用，响应运动，这种作用增加了约80％。这些研究说明了运动过程中内脏床对动脉Gln通量的定量重要性，以及肝脏对空腹和运动的综合作用所引起的代谢需求变化的适应能力。

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