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首页> 外文期刊>American Journal of Physiology >Estrous influences on micturition thresholds of the female rat before and after bladder inflammation.
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Estrous influences on micturition thresholds of the female rat before and after bladder inflammation.

机译：发情对膀胱炎症前后雌性大鼠排尿阈值的影响。

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Recent evidence suggests that lower urinary tract functions may be influenced by reproductive status, particularly under pathophysiological conditions. This study used repeated cystometrograms via a transurethral catheter to investigate the influence of estrous stage on micturition thresholds before and after turpentine-induced bladder inflammation in urethane-anesthetized female rats. Whereas there were no estrous influences on micturition threshold in the uninflamed bladder, micturition thresholds after bladder inflammation were significantly lower in rats in proestrus or estrus than in rats in metestrus or diestrus. Furthermore, the risk that the initial urethral catheterization and preinflammation cystometrogram would produce hematuria was significantly lower in estrus than in the other stages. These estrous influences are not readily explicable by levels of ovarian hormones at the time of testing and may relate instead to dynamic interactions between these hormones and other neuroactive molecules.In addition, the results here have relevance to interpretations of cystometrographic findings in the clinic and basic research.
机译：最近的证据表明，下尿路功能可能受生殖状态的影响，特别是在病理生理条件下。这项研究使用经尿道导管重复的膀胱描记图，以调查在尿烷麻醉的雌性大鼠中，在松节油诱发的膀胱炎症前后，发情期对排尿阈值的影响。未发炎的膀胱的排尿阈值没有发情的影响，发情或发情的大鼠膀胱发炎后的排尿阈值明显低于发情的大鼠或发情的大鼠。此外，发情期初期尿道插管和发炎前膀胱造影术会导致血尿的风险明显低于其他阶段。这些发情的影响在试验时不易通过卵巢激素的水平来解释，而可能与这些激素与其他神经活性分子之间的动态相互作用有关。此外，此处的结果与临床上膀胱镜检查结果的解释和基本原理有关研究。

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