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首页> 外文期刊>American Journal of Physiology >Endothelial vasodilator production by uterine and systemic arteries. IX. eNOS gradients in cycling and pregnant ewes.
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Endothelial vasodilator production by uterine and systemic arteries. IX. eNOS gradients in cycling and pregnant ewes.

机译：子宫和全身动脉产生血管内皮舒张剂。九。循环母羊和怀孕母羊中的eNOS梯度。

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The follicular phase (FOL) and pregnancy exhibit increases in uterine blood flow (UBF), estrogen levels, and uterine artery (UA) endothelial nitric oxide synthase (eNOS) expression. UA branching within the mesometrium increases the total vascular cross-sectional area, which reduces the vascular perfusion pressure gradient, thus locally decreasing the blood flow velocity. Shear stress (SS) activates eNOS and may be associated with UBF elevations during FOL and pregnancy. We hypothesized that regional differences in eNOS responses are observed with both decreases in vessel diameter and during the ovarian cycle and pregnancy. Endothelial isolated proteins were collected from renal (RA) and internal iliac arteries (II) as well as from primary (UA 1 degrees ), secondary (UA 2 degrees), and tertiary (UA 3 degrees) UA branches of nonpregnant luteal phase (LUT; n = 6) and FOL (n = 6) as well as midpregnant (MP; 82 +/- 1 days gestation, n = 6) and late pregnant (LP; 127 +/- 3 days gestation, n 6) ewes (term RA,II, and UA 1 degrees eNOS levels were similar. There was a 60.7 +/- 9.8% reduction in eNOS expression in UA 2 degrees and UA 3 degrees. A similar decreasing eNOS regional expression gradient was observed in LP ewes. No eNOS regional expression gradient was observed in FOL or MP ewes because eNOS increased in UA 2 degrees and UA 3 degrees. In UA 2 degrees and UA 3 degrees, MP > LP = FOL > LUT. Thus, with increasing UBF, FOL and pregnancy rises in SS may regulate eNOS protein expression in smaller diameter UAs. A decrease in LUT and LP UA 2 degrees and UA 3 degrees endothelial eNOS suggest a possible negative feedback mechanism due to downregulation of eNOS if SS is normalized.
机译：卵泡期（FOL）和妊娠期显示子宫血流（UBF），雌激素水平和子宫动脉（UA）内皮一氧化氮合酶（eNOS）表达增加。子宫内膜中的UA分支增加了总的血管横截面积，这减小了血管灌注压力梯度，因此局部降低了血流速度。剪应力（SS）激活eNOS，并可能与FOL和怀孕期间的UBF升高有关。我们假设观察到eNOS反应的区域差异是血管直径的减小以及卵巢周期和妊娠期间的差异。从肾（RA）和内动脉（II）以及从原发性黄体期（LUT）的原发性（UA 1度），继发性（UA 2度）和三级（UA 3度）UA分支中收集内皮分离蛋白; n = 6）和FOL（n = 6）以及中孕（MP;妊娠82 +/- 1天，n = 6）和妊娠晚期（LP;妊娠127 +/- 3天，n 6）母羊（长期RA，II和UA 1度的eNOS水平相似，UA 2度和UA 3度的eNOS表达降低了60.7 +/- 9.8％，LP母羊的eNOS区域表达梯度也下降了。在FOL或MP母羊中观察到eNOS区域表达梯度，因为eNOS在UA 2度和UA 3度中增加;在UA 2度和UA 3度中，MP> LP = FOL> LUT。因此，随着UBF的增加，FOL和妊娠率增加SS中的蛋白可能调节小直径UAs中eNOS蛋白的表达，内皮eNOS的LUT和LP UA 2度和UA 3度下降可能提示阴性如果SS被标准化，则由于eNOS的下调而产生反馈机制。

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