• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Physiology >A model for human ventricular tissue.
【24h】

A model for human ventricular tissue.

机译：人心室组织模型。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The experimental and clinical possibilities for studying cardiac arrhythmias in human ventricular myocardium are very limited. Therefore, the use of alternative methods such as computer simulations is of great importance. In this article we introduce a mathematical model of the action potential of human ventricular cells that, while including a high level of electrophysiological detail, is computationally cost-effective enough to be applied in large-scale spatial simulations for the study of reentrant arrhythmias. The model is based on recent experimental data on most of the major ionic currents: the fast sodium, L-type calcium, transient outward, rapid and slow delayed rectifier, and inward rectifier currents. The model includes a basic calcium dynamics, allowing for the realistic modeling of calcium transients, calcium current inactivation, and the contraction staircase. We are able to reproduce human epicardial, endocardial, and M cell action potentials and show that differences can be explained by differences in the transient outward and slow delayed rectifier currents. Our model reproduces the experimentally observed data on action potential duration restitution, which is an important characteristic for reentrant arrhythmias. The conduction velocity restitution of our model is broader than in other models and agrees better with available data. Finally, we model the dynamics of spiral wave rotation in a two-dimensional sheet of human ventricular tissue and show that the spiral wave follows a complex meandering pattern and has a period of 265 ms. We conclude that the proposed model reproduces a variety of electrophysiological behaviors and provides a basis for studies of reentrant arrhythmias in human ventricular tissue.
机译：研究人心室心肌心律不齐的实验和临床可能性非常有限。因此，使用替代方法（例如计算机仿真）非常重要。在本文中，我们介绍了人心室细胞动作电位的数学模型，该模型虽然包含高水平的电生理细节，但在计算上具有成本效益，足以用于大规模空间模拟，用于研究折返性心律不齐。该模型基于有关大多数主要离子电流的最新实验数据：快速钠，L型钙，瞬态向外，快速和慢速延迟整流器以及向内整流器电流。该模型包括基本的钙动力学，可以对钙瞬变，钙电流失活和收缩阶梯进行逼真的建模。我们能够复制人的心外膜，心内膜和M细胞的动作电位，并表明可以通过瞬态向外和缓慢延迟的整流电流的差异来解释差异。我们的模型再现了关于动作电位持续时间恢复的实验观察数据，这是折返性心律不齐的重要特征。我们模型的传导速度恢复比其他模型更广泛，并且与可用数据更好地吻合。最后，我们对人体心室组织的二维片中螺旋波旋转的动力学进行建模，结果表明螺旋波遵循复杂的曲折模式，周期为265 ms。我们得出的结论是，提出的模型可再现多种电生理行为，并为研究人类心室组织中折返性心律失常提供了基础。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号