• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Physiology >Inhibition of NO production increases myocardial blood flow and oxygen consumption in congestive heart failure.
【24h】

Inhibition of NO production increases myocardial blood flow and oxygen consumption in congestive heart failure.

机译：抑制NO的产生会增加充血性心力衰竭患者的心肌血流量和氧气消耗。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Coronary blood flow (CBF) and myocardial oxygen consumption (MVO(2)) are reduced in dogs with pacing-induced congestive heart failure (CHF), which suggests that energy metabolism is downregulated. Because nitric oxide (NO) can inhibit mitochondrial respiration, we examined the effects of NO inhibition on CBF and MVO(2) in dogs with CHF. CBF and MVO(2) were measured at rest and during treadmill exercise in 10 dogs with CHF produced by rapid ventricular pacing before and after inhibition of NO production with N(G)-nitro-L-arginine (L-NNA, 10 mg/kg iv). The development of CHF was accompanied by decreases in aortic and left ventricular (LV) systolic pressure and an increase in LV end-diastolic pressure (25 +/- 2 mmHg). L-NNA increased MVO(2) at rest (from 3.07 +/- 0.61 to 4.15 +/- 0.80 ml/min) and during exercise; this was accompanied by an increase in CBF at rest (from 31 +/- 2 to 40 +/- 4 ml/min) and during exercise (both P < 0.05). Although L-NNA significantly increased LV systolic pressure, similar increases in pressure produced by phenylephrine did not increase MVO(2). The findings suggest that NO exerts tonic inhibition on respiration in the failing heart.
机译：起搏诱发充血性心力衰竭（CHF）的狗的冠状动脉血流量（CBF）和心肌耗氧量（MVO（2））减少，这表明能量代谢被下调。因为一氧化氮（NO）可以抑制线粒体呼吸，我们检查了CHF犬中NO抑制对CBF和MVO（2）的影响。在10例由快速心室起搏产生的CHF的狗的静止和跑步运动期间测量其CBF和MVO（2），在N（G）-硝基-L-精氨酸（L-NNA，10 mg /公斤iv）。 CHF的发展伴随着主动脉和左心室（LV）收缩压的降低以及左室舒张末期压的升高（25 +/- 2 mmHg）。运动时和运动期间，L-NNA的MVO（2）增加（从3.07 +/- 0.61增至4.15 +/- 0.80 ml / min）;这伴随着静止时（31 +/- 2 ml / min至40 +/- 4 ml / min）和运动中（两者均P <0.05）的CBF升高。尽管L-NNA显着增加了左室收缩压，但去氧肾上腺素产生的压力也没有增加MVO（2）。这些发现表明，NO对衰竭心脏的呼吸作用具有强直抑制作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号