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首页> 外文期刊>American Journal of Physiology >Exercise training increases L-type calcium current density in coronary smooth muscle.
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Exercise training increases L-type calcium current density in coronary smooth muscle.

机译：运动训练可增加冠状动脉平滑肌的L型钙电流密度。

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摘要

Exercise training produces numerous adaptations in the coronary circulation, including an increase in coronary tone, both in conduit and resistance arteries. On the basis of the importance of voltage-gated Ca2+ channels (VGCC) in regulation of vascular tone, we hypothesized that exercise training would increase VGCC current density in coronary smooth muscle. To test this hypothesis, VGCC current was compared in smooth muscle from conduit arteries (>1.0 mm), small arteries (200-250 micrometer), and large arterioles (75-150 micrometer) from endurance-trained (Ex) or sedentary miniature swine (Sed). After 16-20 wk of treadmill training, VGCC current was determined using whole cell voltage-clamp techniques. In both Ex and Sed, VGCC current density was inversely related to arterial diameter, i.e., large arterioles > small arteries > conduit arteries. Exercise training increased peak inward currents approximately twofold in smooth muscle from all arterial sizes compared with those from Sed (large arteriole, -12.52 +/- 2.05 vs. -5.74 +/- 0.99 pA/pF; small artery, -6.20 +/- 0.97 vs. -3.18 +/- 0.44 pA/pF; and conduit arteries, -4.22 +/- 0.30 vs. -2.41 +/- 0.55 pA/pF; 10 mM Ba2+ external). Dihydropyridine sensitivity, voltage dependence, and inactivation kinetics identified this Ca2+ current to be L-type current in all arterial sizes from both Sed and Ex. Furthermore, peak VGCC current density was correlated with treadmill endurance in all arterial sizes. We conclude that smooth muscle L-type Ca2+ current density is increased within the coronary arterial bed by endurance exercise training. This increased VGCC density may provide an important mechanistic link between functional and cellular adaptations in the coronary circulation to exercise training.
机译：运动训练在冠状动脉循环中产生多种适应性，包括导管和阻力动脉中冠状动脉张力的增加。基于电压门控的Ca2 +通道（VGCC）在调节血管紧张度中的重要性，我们假设运动训练会增加冠状动脉平滑肌的VGCC电流密度。为了验证这一假设，比较了耐力训练（Ex）或久坐的小型猪的导管动脉（> 1.0 mm），小动脉（200-250微米）和大动脉（75-150微米）的平滑肌中的VGCC电流。 （Sed）。在跑步机训练16-20周后，使用全电池电压钳技术确定VGCC电流。在Ex和Sed中，VGCC电流密度与动脉直径成反比，即大动脉>小动脉>导管动脉。与Sed相比，运动训练使所有动脉大小的平滑肌的峰值内向电流增加了大约两倍（大动脉为-12.52 +/- 2.05对-5.74 +/- 0.99 pA / pF;小动脉为-6.20 +/- 0.97对-3.18 +/- 0.44 pA / pF;和导管动脉，-4.22 +/- 0.30对-2.41 +/- 0.55 pA / pF; 10 mM Ba2 +外部）。从Sed和Ex来看，在所有动脉大小中，二氢吡啶敏感性，电压依赖性和失活动力学都确定该Ca2 +电流为L型电流。此外，在所有动脉大小中，峰值VGCC电流密度都与跑步机的耐力相关。我们得出的结论是，通过耐力运动训练，平滑肌L型Ca2 +电流密度在冠状动脉床内增加。 VGCC密度的增加可能会在冠状动脉循环中的功能和细胞适应之间提供重要的机械联系，以进行运动训练。

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