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首页> 外文期刊>American Journal of Physiology >Vasomotor responses in chronically hyperperfused and hypoperfused rat mesenteric arteries.
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Vasomotor responses in chronically hyperperfused and hypoperfused rat mesenteric arteries.

机译：慢性高灌注和低灌注大鼠肠系膜动脉的血管舒缩反应。

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We evaluated the reactivity of small arteries after remodeling induced by elevated or reduced blood flow. In 6-wk-old rats, every other first-order side branch of the superior mesenteric artery was ligated near the bifurcation of second-order branches. Four weeks after surgery, vessels that had been exposed to high flow (HF) or low flow (LF) were isolated and mounted in a pressure myograph at 100 mmHg and were compared with vessels from sham-operated rats (Sham). In HF: 1) basal lumen diameter was increased; 2) sensitivity to norepinephrine, arginine vasopressin, and perivascular nerve stimulation was not modified; 3) maximal constrictor responses (delta diameter) to these stimuli and 125 mM K+ were increased; and 4) sensitivity and maximal dilator responses to sodium nitroprusside, acetylcholine, and flow were not modified. In LF: 1) basal diameter was reduced; 2) sensitivity to constrictor stimuli was not altered; 3) maximal responses to all vasoconstrictors except arginine vasopressin were reduced; and 4) sensitivity but not maximal dilator responses to sodium nitroprusside and acetylcholine was reduced. During acute flow-induced dilatations, lower shear stress was maintained in HF (48 +/- 7 dyn/cm2) than in Sham (63 +/- 10 dyn/cm2), but no shear stress regulation was observed in LF. These observations indicate that arterial structural responses to altered blood flow are accompanied by modified reactivity of the arterial smooth muscle, which entails changes in responsiveness to neurogenic and endothelium-dependent stimuli.
机译：我们评估了由高血流或血流减少引起的重塑后小动脉的反应性。在6周龄的大鼠中，肠系膜上动脉的所有其他一阶侧支结扎在二阶分支的分叉附近。手术后四周，将暴露于高流量（HF）或低流量（LF）的血管分离并安装在100 mmHg的压力肌电图仪中，并与假手术大鼠（Sham）的血管进行比较。在HF中：1）基底管腔直径增加; 2）对去甲肾上腺素，精氨酸加压素和血管周神经刺激的敏感性未改变; 3）对这些刺激和125 mM K +的最大收缩反应（δ直径）增加; 4）对硝普钠，乙酰胆碱和血流的敏感性和最大扩张剂反应未改变。在LF中：1）基础直径减小; 2）对收缩刺激的敏感性没有改变; 3）除精氨酸加压素外，对所有血管收缩剂的最大反应均降低; 4）敏感性降低，但扩张剂对硝普钠和乙酰胆碱的最大反应降低。在急性血流引起的扩张中，HF（48 +/- 7 dyn / cm2）保持比Sham（63 +/- 10 dyn / cm2）更低的剪应力，但在LF中未观察到剪应力调节。这些观察结果表明，对改变的血流的动脉结构反应伴随着动脉平滑肌反应性的改变，这导致对神经源性和内皮依赖性刺激的反应性发生变化。

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