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首页> 外文期刊>American Journal of Physiology >Photoperiodic regulation of gene expression in brown and white adipose tissue of Siberian hamsters (Phodopus sungorus).
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Photoperiodic regulation of gene expression in brown and white adipose tissue of Siberian hamsters (Phodopus sungorus).

机译：西伯利亚仓鼠（Phodopus sungorus）棕色和白色脂肪组织中基因表达的光周期调节。

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摘要

Siberian hamsters exhibit seasonal fluctuations in white adipose tissue (WAT) mass, with peaks in long "summerlike" days (LDs) and nadirs in short "winterlike" days (SDs). These responses can be mimicked in the laboratory after transfer from LDs to SDs. The purpose of the present study was to test whether changes in WAT and brown adipose tissue (BAT) gene expression that are mediated by the sympathetic nervous system in other obesity models are also associated with seasonal adiposity changes in Siberian hamsters. SDs decreased WAT mass and leptin mRNA, increased WAT beta(3)-adrenoceptor mRNA, and induced retroperitoneal WAT uncoupling protein-1 mRNA (the latter measured by RT-PCR, others measured by ribonuclease protection assay) while increasing BAT uncoupling protein-1 and peroxisome proliferator-activated receptor-gamma coactivator-1 mRNAs. These effects were not due to SD-induced gonadal regression and largely occurred before the usual SD-induced decreases in food intake. Thus the SD-induced decreased adiposity of Siberian hamsters may be due to a coordinated suite of WAT and BAT gene transcription changes ultimately increasing lipid mobilization and utilization.
机译：西伯利亚仓鼠在白色脂肪组织（WAT）的质量上表现出季节性波动，在“夏季”时期（LDs）较长，而在“冬季”时期（SDs）短时则达到最低点。从LD转移到SD后，可以在实验室中模拟这些响应。本研究的目的是测试在其他肥胖模型中由交感神经系统介导的WAT和棕色脂肪组织（BAT）基因表达的变化是否也与西伯利亚仓鼠的季节性肥胖变化有关。 SD降低WAT量和瘦素mRNA水平，增加WATβ（3）-肾上腺素受体mRNA水平，并诱导腹膜后WAT解偶联蛋白1 mRNA（后者通过RT-PCR测量，其他通过核糖核酸酶保护实验测量），同时增加BAT解偶联蛋白1和过氧化物酶体增殖物激活的受体-γcoactivator-1 mRNAs。这些影响不是由于SD导致的性腺退化所致，而是在通常SD引起的食物摄入减少之前发生的。因此，SD诱导的西伯利亚仓鼠肥胖减少是由于WAT和BAT基因转录变化的协调配合，最终增加了脂质的动员和利用。

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