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首页> 外文期刊>American Journal of Physiology >Seasonality and role of SCN in entrainment of lizard circadian rhythms to daily melatonin injections.
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Seasonality and role of SCN in entrainment of lizard circadian rhythms to daily melatonin injections.

机译：SCN在每天注射褪黑激素的蜥蜴昼夜节律中的季节性和作用。

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摘要

To establish whether the capability of daily melatonin injections to entrain circadian rhythms varies with season, we examined in constant conditions the locomotor behavior of lizards Podarcis sicula collected and subjected to daily melatonin injections at different times of the year. Although in summer locomotor rhythms of both pineal-intact and pinealectomized lizards became entrained to the 24-h injection period, in the other seasons their rhythms did not entrain to the injection period. To establish whether the suprachiasmatic nuclei (SCN) mediate summer entrainment of locomotor rhythms to melatonin, we examined the behavioral effects of daily melatonin injections in lizards subjected to either bilateral (SCN-X) or unilateral (USCN-X) ablation of the SCN. SCN-X lizards became behaviorally arrhythmic, and daily melatonin injections did not restore rhythmicity. USCN-X lizards remained rhythmic, and their locomotor rhythms did entrain to the injections. Besides demonstrating for the first time in a vertebrate that daily melatonin injections are capable of entraining circadian rhythmicity in only one season (summer), the present results support the view that the SCN (and not the pineal gland) are the primary target sites of melatonin in the circadian system of P. sicula.
机译：为了确定每天注射褪黑激素的能力是否能随昼夜节律变化，我们在恒定条件下检查了一年中不同时间收集并接受每天褪黑激素的蜥蜴Podarcis sicula的运动行为。尽管在夏季，松果体完整和松果体切除的蜥蜴的运动节律都在24小时注射期中被夹带了，但在其他季节，它们的节律并没有在注射期中夹带。为了确定上交叉眼核（SCN）是否介导夏季运动神经节律向褪黑激素的夹带，我们检查了每日褪黑激素注射对SCN进行双侧（SCN-X）或单侧（USCN-X）消融的蜥蜴的行为影响。 SCN-X蜥蜴的行为节律失常，每天注射褪黑激素不能恢复节律。 USCN-X蜥蜴保持节律，其运动节律确实会引起注射。除了在脊椎动物中首次证明每日注射褪黑素能够在一个季节（夏季）内具有昼夜节律性外，本研究结果还支持了以下观点：SCN（而非松果体）是褪黑素的主要靶点在P. sicula的昼夜节律系统中。

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