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首页> 外文期刊>American Journal of Physiology >Later endogenous circadian temperature nadir relative to an earlier wake time in older people.
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Later endogenous circadian temperature nadir relative to an earlier wake time in older people.

机译：相对于老年人的较早唤醒时间而言，内源性昼夜节律温度最低点。

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摘要

The contribution of the circadian timing system to the age-related advance of sleep-wake timing was investigated in two experiments. In a constant routine protocol, we found that the average wake time and endogenous circadian phase of 44 older subjects were earlier than that of 101 young men. However, the earlier circadian phase of the older subjects actually occurred later relative to their habitual wake time than it did in young men. These results indicate that an age-related advance of circadian phase cannot fully account for the high prevalence of early morning awakening in healthy older people. In a second study, 13 older subjects and 10 young men were scheduled to a 28-h day, such that they were scheduled to sleep at many circadian phases. Self-reported awakening from scheduled sleep episodes and cognitive throughput during the second half of the wake episode varied markedly as a function of circadian phase in both groups. The rising phase of both rhythms was advanced in the older subjects, suggesting an age-related change in the circadian regulation of sleep-wake propensity. We hypothesize that under entrained conditions, these age-related changes in the relationship between circadian phase and wake time are likely associated with self-selected light exposure at an earlier circadian phase. This earlier exposure to light could account for the earlier clock hour to which the endogenous circadian pacemaker is entrained in older people and thereby further increase their propensity to awaken at an even earlier time.
机译：在两个实验中研究了昼夜节律系统对与年龄相关的睡眠-觉醒定时的贡献。在一个固定的常规方案中，我们发现44位年龄较大的受试者的平均唤醒时间和内源性昼夜节律时间比101位年轻男性的要早。但是，相对于他们的习惯性唤醒时间，年龄较大的受试者的昼夜节律实际上发生的时间比年轻男性的晚。这些结果表明，与年龄有关的昼夜节律的发展不能完全解释健康老年人中清醒的高发生率。在第二项研究中，计划将13个年龄较大的受试者和10个年轻的男性安排为每天28小时，以使他们计划在许多昼夜节律阶段入睡。在两组中，自我报告的计划睡眠事件觉醒和唤醒事件后半部分的认知通量显着不同，其昼夜节律的变化。在较年长的受试者中，两种节律的上升阶段均已进展，表明昼夜节律的觉醒倾向与年龄有关。我们假设在一定的条件下，这些与年龄有关的昼夜节律与苏醒时间之间关系的变化很可能与较早的昼夜节律自选曝光有关。这种较早的曝光可以解释内源性昼夜节律起搏器在老年人中所携带的较早的时钟时间，从而进一步增加了他们在更早的时间醒来的倾向。

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