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首页> 外文期刊>American Journal of Physiology >Effects of homologous atrial natriuretic peptide on drinking and plasma ANG II level in eels.
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Effects of homologous atrial natriuretic peptide on drinking and plasma ANG II level in eels.

机译：同源心钠素对鳗鱼饮酒和血浆ANG II水平的影响。

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摘要

The effects of eel atrial natriuretic peptide (ANP) on drinking were investigated in eels adapted to freshwater (FW) or seawater (SW) or in FW eels whose drinking was stimulated by a 2-ml hemorrhage. An intra-arterial infusion of ANP (0.3-3.0 pmol . kg-1 . min-1), which increased plasma ANP level 1.5- to 20-fold, inhibited drinking dose dependently in all groups of eels. The drinking rate recovered to the level before ANP infusion within 2 h after infusate was replaced by saline. The inhibition at 3.0 pmol . kg-1 . min-1 was profound in FW eels and hemorrhaged FW eels, whereas significant drinking still remained after inhibition in SW eels. Plasma ANG II concentration also decreased dose dependently during ANP infusion and recovered to the initial level after saline infusion in all groups of eels. The decrease at 3.0 pmol . kg-1 . min-1 was large in FW eels and hemorrhaged FW eels compared with that of SW eels. Thus the changes in drinking rate and plasma ANG II level were parallel during ANP infusion. Plasma sodium concentration and osmolality decreased during ANP infusion in SW and FW eels, and they were restored after saline infusion. In hemorrhaged FW eels, however, ANP infusion did not alter plasma sodium concentration and osmolality. Hematocrit did not change during ANP infusion in any group of eels. Collectively, ANP infusion at physiological doses decreased drinking rate and plasma ANG II concentration in parallel in both FW and SW eels. It remains undetermined whether the inhibition of drinking is caused by direct action of ANP or through inhibition of ANG II, which is known as a potent dipsogen in all vertebrate species, including eels.
机译：在适应淡水（FW）或海水（SW）的鳗鱼或因2 ml出血引起饮酒的FW鳗鱼中，研究了鳗鱼心钠素（ANP）对饮酒的影响。动脉内输注ANP（0.3-3.0 pmol。kg-1。min-1）可将血浆ANP水平提高1.5至20倍，在所有鳗鱼组中均依赖于饮酒剂量。在用盐水代替输注液后2小时内，饮水率恢复到ANP输注之前的水平。在3.0 pmol时的抑制作用。千克-1。 min-1在FW鳗鱼和出血性FW鳗鱼中很重要，而在SW鳗鱼抑制后，仍然大量饮酒。在所有鳗鱼组中，血浆ANG II浓度在ANP输注过程中也剂量依赖性降低，并在输注盐水后恢复到初始水平。在3.0 pmol时下降。千克-1。与SW鳗相比，FW鳗和出血的Fel鳗中的min-1较大。因此，在ANP输注期间，饮酒率和血浆ANG II水平的变化是平行的。在SW和FW鳗中，ANP输注期间血浆钠浓度和重量摩尔渗透压浓度降低，而盐水注入后恢复。然而，在出血的鳗鱼中，输注ANP不会改变血浆钠浓度和重量克分子渗透压浓度。在任何一组鳗鱼中，ANP输注期间血细胞比容均未改变。集体地，以生理剂量输注的ANP降低了FW和SW鳗的饮水速度和血浆ANG II浓度。饮酒的抑制作用是由ANP的直接作用还是由ANG II的抑制作用仍未确定，在所有的脊椎动物中，包括鳗鱼，ANG II都被认为是有效的诱变剂。

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