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首页> 外文期刊>American Journal of Physiology >Postnatal maturation of carotid body and type I cell chemoreception in the rat.
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Postnatal maturation of carotid body and type I cell chemoreception in the rat.

机译：大鼠颈动脉体的产后成熟和I型细胞化学感受器。

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摘要

The site of postnatal maturation of carotid body chemoreception is unclear. To test the hypothesis that maturation occurs synchronously in type I cells and the whole carotid body, the development of changes in the intracellular Ca2+ concentration responses to hypoxia, CO2, and combined challenges was studied with fluorescence microscopy in type I cells and compared with the development of carotid sinus nerve (CSN) responses recorded in vitro from term fetal to 3-wk animals. Type I cell responses to all challenges increased between 1 and 8 days and then remained constant, with no multiplicative O2-CO2 interaction at any age. The CSN response to hypoxia also matured by 8 days, but CSN responses to CO2 did not change significantly with age. Multiplicative O2-CO2 interaction occurred in the CSN response at 2-3 wk but not in younger groups. We conclude that type I cell maturation underlies maturation of the CSN response to hypoxia. However, because development of responses to CO2 and combined hypoxia-CO2 challenges differed between type I cells and the CSN, responses to these stimuli must mature at other, unidentified sites within the developing carotid body.
机译：产后颈动脉体化学感受的成熟部位尚不清楚。为了检验I型细胞和整个颈动脉体内同步发生成熟的假说，利用荧光显微镜研究了I型细胞中细胞内Ca2 +浓度对缺氧，CO2和联合挑战的反应变化，并与发育进行了比较。足月胎儿至3周龄动物的颈动脉窦神经（CSN）反应记录。 I型细胞对所有挑战的反应在1到8天之间增加，然后保持恒定，在任何年龄段都没有乘法O2-CO2相互作用。 CSN对缺氧的反应也已经成熟了8天，但是CSN对CO2的反应并没有随着年龄的增长而显着变化。 2-3周时，CSN响应中发生了乘性O2-CO2相互作用，但在较年轻的组中则没有。我们得出结论，I型细胞成熟是CSN对缺氧反应的成熟的基础。但是，由于I型细胞和CSN之间对CO2的反应的发展以及对缺氧-CO2的综合挑战有所不同，因此对这些刺激的反应必须在正在发育的颈动脉体内的其他未知部位成熟。

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