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首页> 外文期刊>American Journal of Physiology >Inflammatory bowel disease is associated with changes of enterocytic junctions.
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Inflammatory bowel disease is associated with changes of enterocytic junctions.

机译：炎症性肠病与肠细胞连接的改变有关。

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摘要

Changes of the intestinal mucosal barrier are considered to play a role in the pathogenesis of inflammatory bowel disease (IBD). Our experiments were designed to identify dysregulation of epithelial junctional molecules in the IBD intestinum and to address whether altered expression of these molecules is a primary event in IBD or a phenomenon secondary to the inflammatory process. Noninflamed and inactively and actively inflamed mucosal tissues from patients with ulcerative colitis or Crohn's disease as well as tissues from control subjects were analyzed for the expression of junctional molecules by different methods. Marked downregulation of junctional proteins and their respective mRNAs was observed in actively inflamed IBD tissues. In IBD tissues with inactive inflammation, only a few junctional molecules such as E-cadherin and alpha-catenin were affected, whereas expression of desmosomal or tight junction-associated proteins appeared almost unchanged. In noninflamed IBD tissues, junctional protein expression was not different from that seen in normal control subjects. In IBD, downregulation of junctional molecule expression is apparently associated with the inflammatory process and does not likely represent a primary phenomenon.
机译：肠粘膜屏障的变化被认为在炎症性肠病（IBD）的发病机理中起作用。我们的实验旨在确定IBD小肠上皮连接分子的失调，并解决这些分子表达的改变是IBD的主要事件还是炎症过程的继发现象。通过不同方法分析了溃疡性结肠炎或克罗恩氏病患者的非发炎，非主动和主动发炎的粘膜组织以及对照组的组织中连接分子的表达。在活跃发炎的IBD组织中观察到连接蛋白及其各自的mRNA的显着下调。在无炎症反应的IBD组织中，仅少数连接分子如E-钙粘着蛋白和α-连环蛋白受到影响，而桥粒或紧密连接相关蛋白的表达几乎没有改变。在未发炎的IBD组织中，连接蛋白的表达与正常对照对象无差异。在IBD中，连接分子表达的下调显然与炎症过程有关，并且不可能代表主要现象。

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