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首页> 外文期刊>American Journal of Physiology >Protective effect of heat shock protein 72 on contractile function of perfused failing heart.
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Protective effect of heat shock protein 72 on contractile function of perfused failing heart.

机译：热休克蛋白72对灌注衰竭心脏收缩功能的保护作用。

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摘要

The contribution of heat shock protein 72 (HSP72) to the protection of cardiac function was examined in rats with chronic heat failure (CHF) following coronary artery ligation (CAL). The CAL animals revealed functional deterioration without low cardiac output 2 wk after CAL and with low cardiac output 8 wk after CAL, suggesting that CHF had developed by 8 wk after CAL. The hearts isolated from animals 2 and 8 wk after CAL (2-wk CAL heart and 8-wk CAL heart, respectively) were subjected to hyperthermia (at 42 degrees C) for 15 min, followed by 6-h perfusion (hyperthermia/6-h perfusion). The 2-wk CAL heart showed a 19.0 +/- 3.9% decline in the rate- pressure product (RPP) after hyperthermia/6-h perfusion, similar to the nonoperated control (19.8 +/- 2.9% decline). The production of myocardial HSP72 increased in the 2-wk CAL heart in response to hyperthermia (412.7 +/- 29.5% of each prehyperthermia value). The 8-wk CAL heart showed a reduction in the RPP (45.2 +/- 4.3% decline) after hyperthermia/6-h perfusion, associated with blunting of the production of HSP72 (68.9 +/- 22.6% increase, respectively). The results suggest that functional deterioration of the isolated failing heart may be attributed to a reduction in the production of myocardial HSP72.
机译：在冠状动脉结扎（CAL）后患有慢性热衰竭（CHF）的大鼠中检查了热休克蛋白72（HSP72）对心脏功能的保护作用。 CAL动物显示功能恶化，在CAL后2 wk没有低心输出量，而在CAL后8 wk有低心输出量，提示CHF在CAL后8 wk发育。从CAL后2周和8周的动物（分别为2周CAL心脏和8周CAL心脏）中分离出的心脏进行高热（42摄氏度）15分钟，然后进行6小时灌注（高热/ 6 -h灌注）。 2周CAL心脏在热疗6 h灌注后显示速率-压力乘积（RPP）下降19.0 +/- 3.9％，与非手术对照组相似（下降19.8 +/- 2.9％）。响应热疗，2-wk CAL心脏中心肌HSP72的产量增加（每个热疗前值的412.7 +/- 29.5％）。 8周CAL心脏在热疗6小时灌流后显示RPP降低（下降45.2 +/- 4.3％），与HSP72产生的减弱（分别增加68.9 +/- 22.6％）相关。结果表明，孤立的衰竭心脏的功能恶化可能归因于心肌HSP72产生的减少。

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