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首页> 外文期刊>American Journal of Physiology >Endothelial E- and P-selectin expression in iNOS- deficient mice exposed to polymicrobial sepsis.
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Endothelial E- and P-selectin expression in iNOS- deficient mice exposed to polymicrobial sepsis.

机译：在暴露于微生物败血症的iNOS缺陷型小鼠中，内皮细胞E和P选择素的表达。

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摘要

In vitro, nitric oxide (NO) decreases leukocyte adhesion to endothelium by attenuating endothelial adhesion molecule expression. In vivo, lipopolysaccharide-induced leukocyte rolling and adhesion was greater in inducible NO synthase (iNOS)-/- mice than in wild-type mice. The objective of this study was to assess E- and P-selectin expression in the microvasculature of iNOS-/- and wild-type mice subjected to acute peritonitis by cecal ligation and perforation (CLP). E- and P-selectin expression were increased in various organs within the peritoneum of wild-type animals after CLP. This CLP-induced upregulation of E- and P-selectin was substantially reduced in iNOS-/- mice. Tissue myeloperoxidase (MPO) activity was increased to a greater extent in the gut of wild-type than in iNOS-/- mice subjected to CLP. In the lung, the reduced expression of E-selectin in iNOS-/- mice was not associated with a decrease in MPO. Our findings indicate that NO derived from iNOS plays an important role in sepsis-induced increase in selectin expression in the systemic and pulmonary circulation. However, in iNOS-/- mice, sepsis-induced leukocyte accumulation is affected in the gut but not in the lungs.
机译：在体外，一氧化氮（NO）通过减弱内皮粘附分子的表达来降低白细胞与内皮的粘附。在体内，与野生型小鼠相比，诱导型NO合酶（iNOS）-/-小鼠中脂多糖诱导的白细胞滚动和粘附更大。这项研究的目的是通过盲肠结扎和穿孔（CLP）评估急性腹膜炎的iNOS-/-和野生型小鼠的微血管中E-和P-选择蛋白的表达。 CLP后，野生型动物腹膜内各个器官的E-和P-选择素表达增加。在iNOS-/-小鼠中，这种CLP诱导的E-和P-选择蛋白上调显着减少。与经受CLP的iNOS-/-小鼠相比，野生型肠道中的组织髓过氧化物酶（MPO）活性增加的程度更大。在肺中，iNOS-/-小鼠中E-选择蛋白的表达降低与MPO降低无关。我们的发现表明，iNOS衍生的NO在脓毒症诱导的全身和肺循环中选择素表达增加中起重要作用。但是，在iNOS-/-小鼠中，败血症诱导的白细胞蓄积在肠道中受到影响，而在肺部则不受影响。

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