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首页> 外文期刊>American Journal of Physiology >Denervation enhances the physiological effects of the K(ATP) channel during fatigue in EDL and soleus muscle.
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Denervation enhances the physiological effects of the K(ATP) channel during fatigue in EDL and soleus muscle.

机译：去神经增强了EDL和比目鱼肌疲劳期间K（ATP）通道的生理作用。

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The objective was to determine whether denervation reduces or enhances the physiological effects of the K(ATP) channel during fatigue in mouse extensor digitorum longus (EDL) and soleus muscle. For this, we measured the effects of 100 microM of pinacidil, a channel opener, and of 10 microM of glibenclamide, a channel blocker, in denervated muscles and compared the data to those observed in innervated muscles from the study of Matar et al. (Matar W, Nosek TM, Wong D, and Renaud JM. Pinacidil suppresses contractility and preserves energy but glibenclamide has no effect during fatigue in skeletal muscle. Am J Physiol Cell Physiol 278: C404-C416, 2000). Pinacidil increased the (86)Rb(+) fractional loss during fatigue, and this effect was 2.6- to 3.4-fold greater in denervated than innervated muscle. Pinacidil also increased the rate of fatigue; for EDL the effect was 2.5-fold greater in denervated than innervated muscle, whereas for soleus the difference was 8.6-fold. A major effect of glibenclamide was anincrease in resting tension during fatigue, which was for the EDL and soleus muscle 2.7- and 1.9-fold greater, respectively, in denervated than innervated muscle. A second major effect of glibenclamide was a reduced capacity to recover force after fatigue, an effect observed only in denervated muscle. We therefore suggest that the physiological effects of the K(ATP) channel are enhanced after denervation.
机译：目的是确定去神经支配是减轻还是增强小鼠趾长指肌（EDL）和比目鱼肌疲劳期间K（ATP）通道的生理效应。为此，我们测量了100微摩尔的吡那地尔（一种通道开放剂）和10微摩尔的格列本脲（一种通道阻断剂）在神经支配的肌肉中的作用，并将这些数据与从Matar等人的研究中在神经支配的肌肉中观察到的数据进行了比较。 （Matar W，Nosek TM，Wong D和Renaud JM。Pinacidil抑制收缩力并保留能量，但格列本脲在骨骼肌疲劳期间没有作用。AmPhysiol Cell Physiol 278：C404-C416，2000）。吡那地尔增加了疲劳期间（86）Rb（+）的部分损失，在神经支配的肌肉中，这种作用比在神经支配的肌肉中增加了2.6-3.4倍。吡那地尔还增加了疲劳率。对于EDL，神经支配肌的效果比神经支配肌的效果高2.5倍，而比目鱼肌的效果则为8.6倍。格列本脲的主要作用是增加疲劳期间的静息张力，这对神经支配的神经比神经支配的EDL和比目鱼肌分别大2.7和1.9倍。格列本脲的第二个主要作用是疲劳后恢复力的能力降低，这种作用仅在失神经的肌肉中观察到。因此，我们建议去神经后增强K（ATP）通道的生理效应。

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