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首页> 外文期刊>American Journal of Physiology >Concurrent elevation of fundic somatostatin prevents gastrin stimulation by GRP.
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Concurrent elevation of fundic somatostatin prevents gastrin stimulation by GRP.

机译：同时增加胃底生长抑素可防止GRP刺激胃泌素。

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摘要

Gastrin-releasing peptide (GRP) can stimulate both gastrin and somatostatin (SOM) secretion, but, as gastrin increases SOM and SOM in turn inhibits gastrin, the overall endpoint in terms of gastrin output is variable. To examine the mechanisms involved, we compared the effects of GRP on gastrin secretion in normal sheep and sheep chronically immunized against SOM. In the normal animal, GRP had no effect on either plasma gastrin or SOM. However, in sheep immunized against SOM, GRP stimulated gastrin secretion, suggesting that the concurrent stimulation of SOM prevents the increase in gastrin secretion. To determine the local source of SOM, GRP was then infused into nonimmunized sheep with cannulas draining blood from the fundus and antrum. GRP stimulated fundic SOM output but inhibited antral SOM and gastrin secretion, demonstrating that the fundus was the source of the SOM. Because cholinergic interactions have a major influence on the effects of GRP, a cholinergic stimulus was administered, and we found that the responses were different: SOM output was inhibited in both the antrum and fundus, and antral gastrin secretion was increased. The present study demonstrates two further instances of the differential regulation of SOM from the antrum and fundus. GRP fails to stimulate gastrin because of an increase in fundic SOM, whereas gastrin levels increase following a cholinergic stimulus because of inhibition of both antral and fundic SOM secretion.
机译：胃泌素释放肽（GRP）可以刺激胃泌素和生长抑素（SOM）分泌，但是，随着胃泌素增加SOM和SOM反过来抑制胃泌素，就胃泌素输出而言，总体终点是可变的。为了检查涉及的机制，我们比较了GRP对正常绵羊和经SOM长期免疫的绵羊胃泌素分泌的影响。在正常动物中，GRP对血浆胃泌素或SOM均无影响。但是，在针对SOM免疫的绵羊中，GRP刺激了胃泌素的分泌，这表明同时刺激SOM可以阻止胃泌素分泌的增加。为了确定SOM的本地来源，然后将GRP注入未免疫的绵羊中，其插管从眼底和胃窦排出血液。 GRP刺激了眼底SOM的输出，但抑制了窦房SOM和胃泌素的分泌，表明眼底是SOM的来源。由于胆碱能相互作用对GRP的影响有很大影响，因此给予了胆碱能刺激，我们发现反应是不同的：胃窦和眼底均抑制了SOM输出，并且胃窦胃泌素的分泌增加。本研究证明了胃窦和眼底对SOM的差异调节的另外两个例子。由于胆碱能的增加，GRP不能刺激胃泌素，而胆碱能刺激后胃泌素的水平会增加，这是因为抑制了胃窦和胃底SOM的分泌。

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