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首页> 外文期刊>American Journal of Physiology >Transport of protein in the abdominal wall during intraperitoneal therapy. I. Theoretical approach.
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Transport of protein in the abdominal wall during intraperitoneal therapy. I. Theoretical approach.

机译：腹膜内治疗期间腹壁中蛋白质的运输。一，理论方法。

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Intraperitoneal therapies such as peritoneal dialysis or regional chemotherapy use large volumes of solution within the peritoneal cavity. These volumes increase intraperitoneal hydrostatic pressure (P(ip)), which causes flow of the solution into tissues that surround the cavity. The goal of this paper is to integrate new experimental findings in a rigorous mathematical model to predict protein transport from the cavity into tissue. The model describes non-steady-state diffusion and convection of protein through a deformable porous medium with simultaneous exchange with the microcirculation and local tissue binding. Model parameters are dependent on local tissue pressure, which varies with P(ip). Solute interactions with the tissue in terms of local distribution volume (solute void space), local binding, and retardation relative to solvent flow are demonstrated to be major determinants of tissue concentration profiles and protein penetration from the peritoneal cavity. The model predicts the rate of fluid loss from the cavity to the abdominal wall in dialysis patients to be 94 ml/h, within the observed range of 60-100 ml/h. The model is fitted to published transport data of IgG, and the retardation coefficient f is estimated to be 0.3, which markedly reduces the rate of protein penetration and is far lower than previously published estimates. With the value of f = 0.3, model calculations predict that P(ip) of 4.4 mmHg and dialysis duration of 24 h result in several millimeters of protein penetration into the tissue.
机译：腹膜内治疗（例如腹膜透析或局部化疗）在腹膜腔内使用大量溶液。这些体积会增加腹膜内静水压力（P（ip）），这会导致溶液流入包围腔的组织中。本文的目的是将新的实验发现整合到严格的数学模型中，以预测蛋白质从腔到组织的转运。该模型描述了通过可变形多孔介质的蛋白质的非稳态扩散和对流，同时与微循环和局部组织结合交换。模型参数取决于局部组织压力，其随P（ip）的变化而变化。溶质与组织之间的相互作用在局部分布体积（溶质空隙空间），局部结合以及相对于溶剂流的阻滞方面已被证明是组织浓度分布和蛋白质从腹膜腔渗透的主要决定因素。该模型预测，透析患者从腔到腹壁的液体流失速率为94 ml / h，在观察到的60-100 ml / h范围内。该模型适合公开发表的IgG转运数据，并且延迟系数f估计为0.3，这显着降低了蛋白质渗透率，并且远低于先前发表的估计。当f = 0.3时，模型计算预测P（ip）为4.4 mmHg，透析持续时间为24 h，导致几毫米的蛋白质渗透到组织中。

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