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首页> 外文期刊>American Journal of Physiology >Regional differences in the response of feline esophageal smooth muscle to stretch and cholinergic stimulation.
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Regional differences in the response of feline esophageal smooth muscle to stretch and cholinergic stimulation.

机译：猫食管平滑肌对拉伸和胆碱能刺激反应的区域差异。

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摘要

There are no objective differences in neural elements that explain regional differences in neural influences along the smooth muscle (SM) esophageal body (EB). Regional differences in muscle properties are present in the lower esophageal sphincter (LES). This study examines whether regional differences in SM properties exist along the EB and are reflected in length-tension relationships and responses to cholinergic excitation. Circular SM strips from feline EB at 1 cm (EB1) and 3 cm (EB3) above LES and from clasp and sling muscle bundles of LES were assessed in normal and calcium-free solutions with and without bethanechol stimulation. Neural inhibition was assessed by electrical field stimulation (EFS). EB3 developed significantly higher tension in response to stretch and to bethanechol than did EB1. The relaxation response to EFS in bethanechol-precontracted strips was less in EB3 than in EB1. In LES, clasp developed higher resting tension than sling but less active tension in response to bethanechol. EFS-induced relaxations of sling and clasp tissues precontracted by bethanechol were not different. In calcium-free solution, length-tension differences between EB3 and EB1 persisted, but those of LES clasp and sling were abolished. Therefore, regional myogenic differences exist in feline EB circular SM as well as in LES and may contribute to the nature of esophageal contraction.
机译：神经元没有客观差异，可以解释沿平滑肌（SM）食道体（EB）的神经影响的区域差异。食管下括约肌（LES）中存在肌肉特性的区域差异。这项研究检查了沿EB的SM特性是否存在区域差异，并反映在长度-张力关系和对胆碱能兴奋的反应中。在正常和无钙溶液中，在有或无乙草胺刺激的情况下，评估了从LES上方1 cm（EB1）和3 cm（EB3）处的猫EB以及LES的钩环和悬带肌束的圆形SM条带。通过电场刺激（EFS）评估神经抑制作用。 EB3对拉伸和对乙二酚的反应产生的张力明显高于EB1。乙三酚预缩条中对EFS的弛豫响应在EB3中比在EB1中小。在LES中，扣环比吊索产生更高的静息张力，但对苯乙二酚的主动张力降低。 EFS引起的苯乙二酚预收缩的吊带和扣环组织松弛没有差异。在无钙溶液中，EB3和EB1之间的长度-张力差异仍然存在，但LES扣和吊索的长度-张力差异被消除。因此，猫EB圆形SM和LES中均存在区域性肌源性差异，可能有助于食管收缩。

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