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首页> 外文期刊>American Journal of Physiology >Bone and hormonal changes induced by skeletal unloading in the mature male rat.
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Bone and hormonal changes induced by skeletal unloading in the mature male rat.

机译：在成年雄性大鼠中骨骼卸载引起的骨骼和激素变化。

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To determine whether the rat hindlimb elevation model can be used to study the effects of spaceflight and loss of gravitational loading on bone in the adult animal, and to examine the effects of age on bone responsiveness to mechanical loading, we studied 6-mo-old rats subjected to hindlimb elevation for up to 5 wk. Loss of weight bearing in the adult induced a mild hypercalcemia, diminished serum 1,25-dihydroxyvitamin D, decreased vertebral bone mass, and blunted the otherwise normal increase in femoral mass associated with bone maturation. Unloading decreased osteoblast numbers and reduced periosteal and cancellous bone formation but had no effect on bone resorption. Mineralizing surface, mineral apposition rate, and bone formation rate decreased during unloading. Our results demonstrate the utility of the adult rat hindlimb elevation model as a means of simulating the loss of gravitational loading on the skeleton, and they show that the effects of nonweight bearing are prolonged and have a greater relative effect on bone formation in the adult than in the young growing animal.
机译：为了确定大鼠后肢抬高模型是否可用于研究成年动物的航天飞行和重力负荷损失对骨骼的影响，以及检查年龄对骨骼对机械负荷反应的影响，我们研究了6个月大的动物大鼠后肢抬高达5周。成人体重减轻导致轻度高钙血症，血清1,25-二羟基维生素D减少，椎骨量减少，以及与骨骼成熟有关的股骨量正常增加的钝化。卸载减少成骨细胞数量并减少骨膜和松质骨形成，但对骨吸收没有影响。在卸载过程中，矿化表面，矿物质沉积速率和骨形成速率降低。我们的研究结果表明，成年大鼠后肢抬高模型可用作模拟重力损失在骨骼上的一种手段，并且它们表明，与成人相比，非负重的作用得以延长，并且对成骨的影响更大。在年轻的成长动物中。

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