• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Physiology >Substance P and NPY differentially potentiate ATP and adrenergic stimulated vasopressin and oxytocin release.
【24h】

Substance P and NPY differentially potentiate ATP and adrenergic stimulated vasopressin and oxytocin release.

机译：P和NPY物质可增强ATP的强度，并刺激肾上腺素刺激的加压素和催产素的释放。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The supraoptic nuclei are innervated by the A1 neurons of the caudal ventrolateral medulla. Substances colocalized in the A1 terminals include norepinephrine (NE), substance P (SP), ATP, and neuropeptide Y (NPY). ATP, acting at P(2x) receptors, caused rapid and unsustained stimulation of vasopressin (VP) and oxytocin (OT) release from perifused explants of the hypothalamo-neurohypophysial system. SP elicited a concentration-dependent stimulation of VP and OT release that was large and sustained compared with other stimuli. ATP, but not phenylephrine (PE, alpha(1)-adrenergic agonist), augmented the response to SP (1 microM). In contrast, NPY did not alter basal nor ATP-induced VP or OT release, but it did cause sustained potentiation of PE-induced VP and OT release. The Y(1)-agonist, [Leu(31),Pro(34)]-NPY, increased VP and OT release, suggesting that the ineffectiveness of NPY reflects opposing actions at pre- and postsynaptic receptors. However, [Leu(31),Pro(34)]-NPY did not potentiate hormone responses to ATP or PE. The differential responses to these colocalized neurotransmitters and neuropeptides illustrate the range of potential responses that stimulation of this pathway might elicit from supraoptic neurons.
机译：视上核由尾侧腹外侧延髓的A1神经元支配。在A1末端共定位的物质包括去甲肾上腺素（NE），物质P（SP），ATP和神经肽Y（NPY）。 ATP，作用于P（2x）受体，引起下丘脑-神经下垂体系统外植体的加压素（VP）和催产素（OT）释放的快速和不持久刺激。 SP引起浓度依赖性的VP和OT释放刺激，与其他刺激相比，这种刺激很大且持续。 ATP，而不是去氧肾上腺素（PE，α（1）-肾上腺素激动剂），增加了对SP的反应（1 microM）。相比之下，NPY不会改变基础或ATP诱导的VP或OT释放，但会引起PE诱导的VP和OT释放的持续增强。 Y（1）激动剂，[Leu（31），Pro（34）]-NPY，增加VP和OT释放，表明NPY的无效反映了突触前和突触后受体的相反作用。但是，[Leu（31），Pro（34）]-NPY不能增强激素对ATP或PE的反应。对这些共定位的神经递质和神经肽的不同反应，说明了该途径的刺激可能由视上神经元引起的潜在反应范围。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号